Medisinsk fakultet Universitetet i Bergen Hanne Sether Lilleberg er medisinstudent med lisens. Forfatter har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. IVAR ANDERS EIDE Nyremedisinsk avdeling Akershus universitetssykehus Ivar Anders Eide er ph.d., spesialist i nyremedisin og overlege. Forfatter har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. JOHN TERJE GEITUNG Radiologisk avdeling Akershus universitetssykehus John Terje Geitung er professor og overlege. Forfatter har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. MY HANNA SOFIA SVENSSON Nyremedisinsk avdeling Akershus universitetssykehus My Hanna Sofia Svensson er ph.d., spesialist i nyremedisin og professor. Forfatter har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. En ung kvinne ble rammet av feber, generelle ødemer, leddsmerter og tungpust. En i utgangspunktet forbigående, harmløs infeksjon viste seg her gjennom et alvorligere forløp med akutt glomerulonefritt.
Resting heart rate (rHR) and heart rate variability (HRV) are non-invasive measurements that predict the risk of sudden cardiac death (SCD). Marine n-3 polyunsaturated fatty acid (PUFA) supplementation may decrease rHR, increase HRV, and reduce the risk of SCD. To date, no studies have investigated the effect of marine n-3 PUFA on HRV in renal transplant recipients. In a randomized controlled trial, 132 renal transplant recipients were randomized to receive either three 1 g capsules of marine n-3 PUFA, each containing 460 mg/g EPA and 380 mg/g DHA, or control (olive oil) for 44 weeks. HRV was calculated in the time and frequency domains during a conventional cardiovascular reflex test (response to standing, deep breathing, and Valsalva maneuver) and during 2 min of resting in the supine position. There was no significant effect of marine n-3 PUFA supplementation on time-domain HRV compared with controls. rHR decreased 3.1 bpm (± 13.1) for patients receiving marine n-3 PUFA compared to 0.8 (± 11.0) in controls (p = 0.28). In the frequency domain HRV analyses, there was a significant change in response to standing in both high and low frequency measures, 2.9 (p = 0.04, 95% CI (1.1;8)) and 2.7 (p = 0.04, 95% CI (1.1;6.5)), respectively. In conclusion, 44 weeks of supplemental marine n-3 PUFAs in renal transplant recipients significantly improved the cardiac autonomic function, assessed by measuring HRV during conventional cardiovascular reflex tests.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.