Background
In the current study, we aimed to investigate the effect of smoking on inadequate response to Methotrexate (MTX-IR) in rheumatoid arthritis (RA) patients.
Methods
We searched PubMed, Embase, and Web of Science until 6 June 2022. Observational or interventional studies investigating MTX-IR in RA patients based on smoking status were included. Two independent reviewers assessed the risk of bias and the certainty of the evidence using ROBINS-I and grades of recommendation, assessment, development, and evaluation (GRADE) tools, respectively.
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