This study performed an epidemiological survey of Neisseria meningitidis strains isolated from patients and from asymptomatic carriers. Altogether, 74 N. meningitidis strains (46 invasive and 28 non-invasive) were isolated between February 2011 and May 2018 in different regions of the Republic of Belarus. Serogenotyping was carried out by real-time PCR. Minimum inhibitory concentrations (MICs) of antibiotics were determined by broth microdilution and results were interpreted in accordance with EUCAST. The serogroups of N. meningitidis were determined as follows: serogroup B-65%, C-11%, W-9%, A-5%, Y-4%, and Z and NG-3% each. The MIC 50 and MIC 90 for benzylpenicillin (0.
Meningococci circulating among the population of the Republic of Belarus during the observed pre-vaccination interepidemic period (2006–2019) is characterized by dynamism. A change in the serogroup structure was noted with a decrease of meningococci serogroup A and non-grouped strains; an increase of meningococci serogroups B and Z. Elimination of MenE and the emergence of MenW were observed. “Belarusian” meningococci are part of 13 known clonal complexes. CC-103 is represented by endemic ST and is associated with MenB and MenW; CC-41/44 evenly included serogroups B and C. CC-11 is responsible for the outbreak of meningococcal infection in 2016-2018 caused
by ST-11 MenW. CC-18 was characterized by the proliferation of serogroups B and C. Clonal complexes CC-53, CC-174 and CC-1136 represented by various meningococcal serogroups in the world population were associated in the territory of Belarus with MenB, MenC and MenA respectively. Among the ST CC-103 and CC-41/44 registered in the world, “Belarusian” meningococci are phylogenetically represented as a separate cluster.
SENSITIVITY TO BENZYLPENICILLIN OF N.MENINGITIDIS ISOLATED FROM CHILDREN UNDER 5 YEARS WITH INVASIVE BACTERIAL DISEASES Results
N.meningitidis isolates characterization28 isolates of N.meningitidis were serogroups B
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.