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Background: Numerous trials have demonstrated high efficacy and safety of artemisinin-based combination therapy (ACT) under supervised treatment. In contrast, effectiveness studies comparing different types of ACT applied unsupervised are scarce. The aim of this study was to compare effectiveness, tolerability and acceptance of artesunate plus amodiaquine (ASAQ) against that of artemether-lumefantrine (AL) in Ghanaian children with uncomplicated Plasmodium falciparum malaria.

Bats have been implicated as reservoirs of emerging viruses. Bat species forming large social groups and roosting in proximity to human communities are of particular interest. In this study, we sampled a colony of ca. 350,000 individuals of the straw-colored fruit bat Eidolon helvum in Kumasi, the second largest city of Ghana. A novel rhabdovirus (Kumasi rhabdovirus [KRV]) was isolated in E. helvum cell cultures and passaged to Vero cells as well as interferon-competent human and primate cells (A549 and MA104). Genome composition was typical for a rhabdovirus. KRV was detected in 5.1% of 487 animals, showing association with the spleen but not the brain. Antibody prevalence was 11.5% by immunofluorescence and 6.4% by plaque reduction virus neutralization test (PRNT). Detection throughout 3 sampling years was pronounced in both annual wet seasons, of which only one overlaps the postparturition season. Juvenile bats showed increased viral prevalence. No evidence of infection was obtained in 1,240 female mosquitos (6 different genera) trapped in proximity to the colony to investigate potential vector association. Antibodies were found in 28.9% (5.4% by PRNT) of 107 swine sera but not in similarly large collections of sheep, goat, or cattle sera. The antibody detection rate in human subjects with occupational exposure to the bat colony was 11% (5/45 persons), which was significantly higher than in unexposed adults (0.8% [1/118]; chi square, P < 0.001). KRV is a novel bat-associated rhabdovirus potentially transmitted to humans and swine. Disease associations should be investigated. IMPORTANCEBats are thought to carry a huge number of as-yet-undiscovered viruses that may pose epidemic threats to humans and livestock. Here we describe a novel dimarhabdovirus which we isolated from a large colony of the straw-colored fruit bat Eidolon helvum in Ghana. As these animals are exposed to humans and several livestock species, we looked for antibodies indicating infection in humans, cattle, swine, sheep, and goats. Signs of infection were found in swine and humans, with increased antibody findings in humans who are occupationally exposed to the bat colony. Our data suggest that it is worthwhile to look for diseases caused by the novel virus in humans and livestock.T he recognition of novel and emerging viral diseases requires knowledge of potential viral reservoirs. Small mammals may constitute important sources of novel viruses for humans and mammalian livestock. We and others have identified considerable diversities of reservoir-borne viruses, including paramyxoviruses, coronaviruses, filoviruses, lyssaviruses, hepaciviruses, and hepadnaviruses, in small mammals such as rodents and bats. Reservoirborne viruses typically show a larger genetic diversity than their counterparts in other hosts, including humans and livestock (1-4). Small mammals have certain properties that promote viral maintenance, diversification, and spread, such as high population turnover in the case of rodents or large sizes and densities of soci...

A recent report suggested that 2 novel bunyaviruses discovered in insects in Côte d’Ivoire caused lethal disease in swine in South Korea. We conducted cell culture studies and tested serum from pigs exposed to mosquitoes in Côte d’Ivoire and Ghana and found no evidence for infection in pigs.

The Australian monsoon delivers seasonal rain across a vast area of the continent stretching from the far northern tropics to the semi-arid regions. This article provides a review of advances in Australian monsoon rainfall (AUMR) research and a supporting analysis of AUMR variability, observed trends, and future projections. AUMR displays a high degree of interannual variability with a standard deviation of approximately 34% of the mean. AUMR variability is mostly driven by the El Niño-Southern Oscillation (ENSO), although sea surface temperature anomalies in the tropical Indian Ocean and north of Australia also play a role. Decadal AUMR variability is strongly linked to the Interdecadal Pacific Oscillation (IPO), partially through the IPO's impact on the strength and position of the Pacific Walker Circulation and the South Pacific Convergence Zone. AUMR exhibits a century-long positive trend, which is large (approximately 20 mm per decade) and statistically significant over northwest Australia. The cause of the observed trend is still debated. Future changes in AUMR over the next century remain uncertain due to low climate model agreement on the sign of change. Recommendations to improve the understanding of AUMR and confidence in AUMR projections are provided. This includes improving the representation of atmospheric convective processes in models, further explaining the mechanisms responsible for AUMR variability and change. Clarifying the mechanisms of AUMR variability and