Background:The identity of natural substrate proteins of small heat shock proteins is poorly understood. Results: A total of 95 and 54 natural substrate proteins were identified for IbpB in living cells at 50 and 30°C, respectively. Conclusion: IbpB preferentially protects translation-related proteins and metabolic enzymes. Significance: This study offers mechanistic insights into the chaperone functions of small heat shock proteins for cells against stresses.
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