Chronic cough is one of the most common complaints of childhood to consult a doctor. There are many causes such as respiratory tract infections, gastroesophageal reflux, persistent bacterial bronchitis, asthma, cystic fibrosis, congenital malformations, and foreign body aspiration in children under the age of five. However, neither transient hypogammaglobulinemia of infancy (THI) among the causes of chronic cough, nor chronic cough among the application complaints of THI are not questioned. In this study, we aimed to draw attention to the role of THI in the etiology of chronic cough under the age of five. Our study included 55 pediatric patients under the age of five who applied to the pediatric pulmonary diseases outpatient clinic in between January 2015 and December 2020 with the complaint of chronic cough, who were excluded from other causes of chronic cough in etiology, and who met the criteria for THI according to the European Society for Immunodeficiencies (ESID). Demographic, clinical and laboratory characteristics and follow-ups of these patients were reviewed retrospectively. In our study, the mean age of 55 patients at admission was 21.73 ± 11.50 months (median age: 18 months), and the mean age of IgG recovery was 38.65 ± 16.81 months. The mean recovery time was 16.93 ± 12.85 months. Of the patients, 22.4% had a history of consanguinity, 23.4% had prematurity, and 18.2% had a frequent sickness in siblings. The most common complaint accompanying chronic cough in patients was frequent respiratory tract infection, 16.3%. Along with IgG, 26.4% of the patients had low IgA and 31.5% had low IgM in laboratory testing. In antibody responses, isohemagglutinin, anti-tetanus, anti-pneumococcal, anti-HBs vaccine responses were found to be positive in 90.6%, 63.9%, 66.7% and 97.7% of the cases, respectively. 72.7% of the patients received inhaler treatment, 45.5% received antibiotic prophylaxis, and 2.2% received intravenous immunoglobulin (IVIg) treatment. After the IgG value of the patients returned to normal, it was observed that 86.3% of the patients’ cough complaint have disappeared. Transient hypogammaglobulinemia of infancy mostly presents with recurrent lower and upper respiratory tract infections. The most common complaint is cough. It is not questioned whether the cough is chronic or not. In this study, we aimed to investigate the follow-up and prognosis of patients under the age of five who had a chronic cough complaint, when other causes of cough were ruled out and THI was detected. In the study, when the IgG levels of the patients return to normal, the cough complaints disappear to a large extent, showing that THI may also be among the causes of chronic cough.
Introduction: Pediatric poisoning is a common cause of emergency department admissions. The epidemiology of pediatric poisonings can vary in different countries, even different regions of the same country. It is important to determine the regional factors to decrease morbidity and mortality. This study was aimed to evaluate the epidemiological features, clinical signs, and risk factors of pediatric poisonings. Material and Method:This retrospective descriptive study was carried out in the pediatric emergency department of a tertiary hospital and medical records between January 2016 and December 2020 were retrospectively reviewed. Demographic characteristics, laboratory results, and treatments were recorded.Results: 835 patients aged 4 months-18 years including 450 females (53.9%) were included in the study. Poisonings were most common in summer (n=280, 33.5%) and in the daytime (n=490, 58.7%). The mean age of suicidal poisoning was significantly higher then accidental poisonings (p<0.001). Pharmaceutical agents were statistically significantly higher in patients poisoned due to suicidal attempts (p<0.001). On the other hand, there was not a statistically significant difference between accidental and suicidal poisoning in terms of clinical presentation, length of stay in the hospital, and, intensive care unit requirement (p>0.05). Conclusions:Childhood poisoning is one of the important emergencies that need attention. Pediatric emergency physicians should always keep in mind the possibility of poisoning, even with the lack of medical history. It could be estimated the possible ingested agents according to the age group, and this allows physicians to avoid delay in treatment of these patients.
BackgroundCystic fibrosis (CF) is an autosomal recessive disorder caused by CF transmembrane conductance regulator (CFTR) genetic variants. CFTR modulators improve pulmonary function and reduce respiratory infections in CF. This study investigated the clinical and laboratory follow‐up parameters over 1 year in patients with CF who could not receive this treatment.MethodsThis retrospective cohort study included 2018 and 2019 CF patient data from the CF registry of Turkey. Demographic and clinical characteristics of 294 patients were assessed, who had modulator treatment indications in 2018 but could not reach the treatment.ResultsIn 2019, patients younger than 18 years had significantly lower BMI z‐scores than in 2018. During the 1‐year follow‐up, forced expiratory volumes (FEV1) and FEV1 z‐scores a trend toward a decrease. In 2019, chronic Staphylococcus aureus colonization, inhaled antipseudomonal antibiotic use for more than 3 months, oral nutritional supplement requirements, and oxygen support need increased.ConclusionsPatients who had indications for modulator treatments but were unable to obtain them worsened even after a year of follow‐up. This study emphasized the importance of using modulator treatments for patients with CF in our country, as well as in many countries worldwide.
This study aims to investigate and analyze the clinical features of coexisting human bocavirus (HBoV) positivity and plastic bronchitis (PB). We present three cases with no known history of cardiac surgery who presented with cough, progressive dyspnea, and atelectasis. They tested positive for HBoV in a real-time polymerase chain reaction of both nasal lavage fluids. They were diagnosed with PB as a result of bronchoscopy and pathology. PB is a rare disease characterized by forming thick rigid casts in the tracheobronchial tree, which can progress to respiratory failure. While asthma or atopy-related type 1 PB was observed in one patient, two patients were diagnosed with PB, which was thought to have developed secondary to viral infections of unknown etiology. As far as we know, HBoV-associated PB cases are rare in the literature. Besides the commonly known infectious agents, we identified a relationship with HBoV in all the presented cases.
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