Among the regulatory mechanisms of the renewal and differentiation of neural stem cells, recent evidences support that epigenetic modifications such as DNA methylation, histone modification, and noncoding RNAs play critical roles in the regulation on the proliferation and differentiation of neural stem cells. In this review, we discussed recent advances of DNA modifications on the regulative mechanisms of neural stem cells. Among these epigenetic modifications, DNA 5-hydroxymethylcytosine (5hmC) modification is emerging as an important modulator on the proliferation and differentiation of neural stem cells. At the same time, Ten-eleven translocation (Tet) methylcytosine dioxygenases, the rate-limiting enzyme for the 5-hydroxymethylation reaction from 5-methylcytosine to 5-hydroxymethylcytosine, play a critical role in the tumorigenesis and the proliferation and differentiation of stem cells. The functions of 5hmC and TET proteins on neural stem cells and their roles in neurological diseases are discussed.

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Aim: Roles of DNA 5-hydroxymethylcytosine (5hmC) in myelin repair were investigated in an experimental autoimmune encephalomyelitis (EAE) mouse model via its regulation on BDNF. Methods: DNA 5hmC level and its limiting enzymes were detected in EAE mice. Results: Global 5hmC modification, Tet1 and Tet2 significantly decreased in the spinal cord tissues of EAE mice. BDNF protein and mRNA decreased and were highly associated with BDNF 5hmC. Vitamin C, a Tet co-factor, increased global DNA 5hmC and reduced the neurological deficits at least by increasing BDNF 5hmC modification and protein levels. Conclusion: Tet protein-mediated 5hmC modifications represent a critical target involved in EAE-induced myelin damage. Targeting epigenetic modification may be a therapeutic strategy for multiple sclerosis.

Dynamically switchable light transmission/absorption functionality is highly desirable in sensing and functional devices. However, the operating bandwidth of the newly emerging schemes using resonant meta-structures is inherently limited. In this work, we design and numerically demonstrate a non-resonant tilted anisotropic metamaterial consisting of phase-change materials. When the phase transition of the phase-change material from amorphous phase to crystalline phase occurs, the functionality of the metamaterial can be switched from perfect transparency to perfect absorption for transverse-magnetic polarization under oblique incidence over a broad spectrum. Such a remarkable phenomenon originates in the anomalous Brewster effect, which enables broadband reflectionless transmission/absorption of light under the anomalous Brewster’s angle. Moreover, gradient metamaterials exhibiting dynamically controllable functionality for incident light with an almost arbitrary wavefront are demonstrated. The proposed metamaterials are simple but highly efficient, which may find applications in sensing and advanced and intelligent optical devices.