Abstract-Phase change memory (PCM) is a promising technology that can offer higher capacity than DRAM. Unfortunately, PCM's access latency and energy are higher than DRAM's and its endurance is lower. Many DRAM-PCM hybrid memory systems use DRAM as a cache to PCM, to achieve the low access latency and energy, and high endurance of DRAM, while taking advantage of PCM's large capacity. A key question is what data to cache in DRAM to best exploit the advantages of each technology while avoiding its disadvantages as much as possible.We propose a new caching policy that improves hybrid memory performance and energy efficiency. Our observation is that both DRAM and PCM banks employ row buffers that act as a cache for the most recently accessed memory row. Accesses that are row buffer hits incur similar latencies (and energy consumption) in DRAM and PCM, whereas accesses that are row buffer misses incur longer latencies (and higher energy consumption) in PCM. To exploit this, we devise a policy that avoids accessing in PCM data that frequently causes row buffer misses because such accesses are costly in terms of both latency and energy. Our policy tracks the row buffer miss counts of recently used rows in PCM, and caches in DRAM the rows that are predicted to incur frequent row buffer misses. Our proposed caching policy also takes into account the high write latencies of PCM, in addition to row buffer locality.Compared to a conventional DRAM-PCM hybrid memory system, our row buffer locality-aware caching policy improves system performance by 14% and energy efficiency by 10% on data-intensive server and cloud-type workloads. The proposed policy achieves 31% performance gain over an all-PCM memory system, and comes within 29% of the performance of an all-DRAM memory system (not taking PCM's capacity benefit into account) on evaluated workloads.

Abstract-Hybrid main memories composed of DRAM as a cache to scalable non-volatile memories such as phase-change memory (PCM) can provide much larger storage capacity than traditional main memories. A key challenge for enabling high-performance and scalable hybrid memories, though, is efficiently managing the metadata (e.g., tags) for data cached in DRAM at a fine granularity. Based on the observation that storing metadata off-chip in the same row as their data exploits DRAM row buffer locality, this paper reduces the overhead of fine-granularity DRAM caches by only caching the metadata for recently accessed rows on-chip using a small buffer. Leveraging the flexibility and efficiency of such a fine-granularity DRAM cache, we also develop an adaptive policy to choose the best granularity when migrating data into DRAM. On a hybrid memory with a 512MB DRAM cache, our proposal using an 8KB on-chip buffer can achieve within 6% of the performance of, and 18% better energy efficiency than, a conventional 8MB SRAM metadata store, even when the energy overhead due to large SRAM metadata storage is not considered.

New phase-change memory (PCM) devices have low-access latencies (like DRAM) and high capacities (i.e., low cost per bit, like Flash). In addition to being able to scale to smaller cell sizes than DRAM, a PCM cell can also store multiple bits per cell (referred to as multilevel cell, or MLC), enabling even greater capacity per bit. However, reading and writing the different bits of data from and to an MLC PCM cell requires different amounts of time: one bit is read or written first, followed by another. Due to this asymmetric access process, the bits in an MLC PCM cell have different access latency and energy depending on which bit in the cell is being read or written. We leverage this observation to design a new way to store and buffer data in MLC PCM devices. While traditional devices couple the bits in each cell next to one another in the address space, our key idea is to logically decouple the bits in each cell into two separate regions depending on their read/write characteristics: fast-read/slow-write bits and slow-read/fast-write bits. We propose a low-overhead hardware/software technique to predict and map data that would benefit from being in each region at runtime. In addition, we show how MLC bit decoupling provides more flexibility in the way data is buffered in the device, enabling more efficient use of existing device buffer space. Our evaluations for a multicore system show that MLC bit decoupling improves system performance by 19.2%, memory energy efficiency by 14.4%, and thread fairness by 19.3% over a state-of-the-art MLC PCM system that couples the bits in its cells. We show that our results are consistent across a variety of workloads and system configurations.

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Primary liver tumor, especially hepatocellular carcinoma (HCC), is a common cause of cancer death worldwide. The incidence is generally higher in Asian countries than in western countries. Carcinogenesis of HCC is often associated with hepatitis viral infections. Current standard treatment of HCC is surgical resection or transplantation in patients with early stage disease. However, the patient with advanced stage disease, surgical resection is often limited. Sorafenib or other treatment modalities are not so effective as well. We report a case of unusual radiation super-sensitivity in advanced stage HCC, and review the literature.