The performance of vanadia-doped zirconia-pillared clay (V/Zr-PILC) for the selective catalytic oxidation of H 2 S was investigated in this study. A series of vanadia-doped zirconia pillared clays (V/Zr-PILCs) with various amounts of vanadia were prepared and characterized using X-ray diffraction (XRD), surface area-pore volume measurements, chemical analysis, infrared (FTIR) spectroscopy, UV-vis-diffuse reflectance spectroscopy (UV-vis-DRS), X-ray photoelectron spectroscopy (XPS), and thermogravimetric (TG) analysis. V/Zr-PILCs showed better catalytic performance than Zr-PILC at temperatures ranging from 220-300 C without any considerable SO 2 emission. The H 2 S conversion over V/Zr-PILCs increased with increasing vanadia content up to 6 wt%. However, it decreased at higher vanadia loadings due to the decrease of surface area and to the formation of the crystalline V 2 O 5 phase. The results of a regeneration experiment using 6 wt% V/Zr-PILC catalyst showed good reproducibility in its catalytic activity, even through five successive sulfidation-regeneration cycles at 280 C.

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Lung cancer is the second most common cancer in the United States and the leading cause of mortality in cancer patients. Biomarkers predicting survival of patients with lung cancer have a profound effect on patient prognosis and treatment. However, predictive biomarkers for survival and their relevance for lung cancer are not been well known yet. The objective of this study was to perform machine learning with data from The Cancer Genome Atlas of patients with lung adenocarcinoma (LUAD) to find survival-specific gene mutations that could be used as survival-predicting biomarkers. To identify survival-specific mutations according to various clinical factors, four feature selection methods (information gain, chi-squared test, minimum redundancy maximum relevance, and correlation) were used. Extracted survival-specific mutations of LUAD were applied individually or as a group for Kaplan-Meier survival analysis. Mutations in MMRN2 and GMPPA were significantly associated with patient mortality while those in ZNF560 and SETX were associated with patient survival. Mutations in DNAJC2 and MMRN2 showed significant negative association with overall survival while mutations in ZNF560 showed significant positive association with overall survival. Mutations in MMRN2 showed significant negative association with disease-free survival while mutations in DRD3 and ZNF560 showed positive associated with disease-free survival. Mutations in DRD3, SETX, and ZNF560 showed significant positive association with survival in patients with LUAD while the opposite was true for mutations in DNAJC2, GMPPA, and MMRN2. These gene mutations were also found in other cohorts of LUAD, lung squamous cell carcinoma, and small cell lung cancer. In LUAD of Pan-Lung Cancer cohort, mutations in GMPPA, DNAJC2, and MMRN2 showed significant negative associations with survival of patients while mutations in DRD3 and SETX showed significant positive association with survival. In this study, machine learning was conducted to obtain information necessary to discover specific gene mutations associated with the survival of patients with LUAD. Mutations in the above six genes could predict survival rate and disease-free survival rate in patients with LUAD. Thus, they are important biomarker candidates for prognosis.

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