Background
Macrophages play a crucial role in the pathogenesis of rheumatoid arthritis (RA). Growth differentiation factor‐15 (GDF‐15) acts as an autocrine regulator of macrophage activation. Objective: The aim of this study was to assess serum level of GDF‐15 as a potential biomarker for detecting RA activity.
Method
A total of 100 female RA patients and 55 age and weight matched healthy control females were enroled. The serum level of GDF‐15 was measured using enzyme‐linked immunosorbent assay.
Results
Serum levels of GDF‐15 in RA patients with high, moderate, low and no disease activity were 989.0 ± 161.9, 505.6 ± 220.5, 349.2 ± 155.9 and 349.0 ± 144.0 pg/mL, respectively. GDF‐15 with a cut‐off value higher than 705 pg/mL was indicative of high RA activity with sensitivity of 96% and specificity of 92%.
Conclusion
GDF‐15 serum levels may be used as a biomarker to predict high RA disease activity.
Background: Macrophages play a crucial role in the pathogenesis of rheumatoid arthritis (RA). Growth differentiation factor-15 (GDF-15) acts as an autocrine regulator of macrophage activation. Objective: The aim of this study was to assess serum level of GDF-15 as a potential biomarker for detecting RA activity. Method: A total of 100 female RA patients and 55 age matched healthy control females were enrolled. The serum level of GDF-15 was measured using enzyme-linked immunosorbent assay by an eBioscience kit. Results: Serum levels of GDF-15 in RA patients with high, moderate, low and no disease activity were 989.0±161.9, 505.6±220.5, 349.2±155.9 and 349.0±144.0 pg/ml, respectively. GDF-15 with a cut-off value higher than 705 pg/ml was indicative of high RA activity with sensitivity of 96% and specificity of 92%. Conclusion: GDF-15 serum levels may be used as a biomarker to predict high RA disease activity.
Title pageThe association between serum levels of growth differentiation factor-15 and rheumatoid arthritis activity
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