Background and Objectives: Vitamin C or ascorbic acid is the most efficient water-soluble antioxidant. Studies show intravenous and oral vitamin C assist with burn healing. However, the effects of topical applications of vitamin C remain unstudied. This study aimed to evaluate the effects of topical vitamin C solution on the granulation tissue reduction of second-degree burn wounds. Methods: This clinical trial was conducted on 30 patients with second-degree burns affecting two or more regions or extended limb areas who had been admitted to the Vasee Hospital burn unit in Sabzevar, Iran during Aug-Dec 2016. In light of the multiple factors influencing burn wound healing, each subject served as his or her own control. Additionally, the depth of burn wounds in each area between limbs of the same patient was similar. Patients routinely received sulfadiazine ointment on two contiguous or separate body parts. Vitamin C solution was applied to one randomly chosen part of the body or one randomly chosen limb. Burn wounds were examined on days one (a baseline measure) and three, seven, and 14 days after the initial assessment, using the Bates-Jensen Wound Assessment Tool. Written informed consent was obtained from the patients prior to the study. Data analysis was performed in SPSS version 20 using repeated measures ANOVA. Results: In the experimental region, the mean granulation score was 5.00 ± 0.00 at baseline and reached 1.83 ± 0.87 on day 14. In the control group, mean granulation score was 5.00 ± 0.00 at baseline and increased to 2.67 ± 0.88 on day 14. On day 14, a significant difference was observed between the mean granulation scores for the experimental and control regions (P = 0.004). Conclusions: Topical administration of a vitamin C solution could be effective in promoting the healing of second-degree burn wounds.
Background and Purpose: Vitamin C is administered orally or intravenously for the treatment of burn wounds. However, effects of the topical application of vitamin C remain unclear. This study aimed to evaluate the effects of topical vitamin C solution on the necrotic tissue volume of second-degree burn wounds.
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