In this article, we report a 34-year-old man who presented with a buccal progressive ulcerated lesion which through histopathologic and IHC findings diagnosed as Peripheral T-cell lymphoma.

Background Peripheral T‐Cell Lymphoma Not Otherwise Specified (PTCL‐NOS) is a rare type of non‐Hodgkin T‐cell lymphoma which frequently seen in immunocompromised individuals. It is estimated that only 2% of lymphomas are located on the buccal mucosa. In this case report, we present a 34‐year‐old male with a PTCL diagnosis. Case A 34‐year‐old immune‐competent male presented with a buccal progressive ulcerated lesion. Histopathologic and immunohistochemical findings were compatible with PTCL‐NOS and classified as stage IIEA according to the Ann Arbor staging. The patient underwent chemotherapy followed by radiotherapy. He remained disease‐free after 12 months of follow‐up. Conclusion Although lymphoma is uncommon in the oral cavity, physicians especially dentists in ordinary dental checkups should consider persistent progressive lesions as an important differential diagnosis of lymphoma.