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The levels of arylsulfatases A and B, α-amylase, aspartate transcarbamylase, and γ-glutamyl transpeptidase were investigated during the infection of mice with schistosoma mansoni. This infection caused a significant (p<0.001) increase in the activity of hepatic arylsulfatase B (ASB), aspartate transcarbamylases and γ-glutamyl transpeptidase. A non-significant difference occurred for α-amylase (p<0.3) and arylsulfatase A (p>0.5) when compared to the control. The specific activity of hepatic ASB was progressively increased with the progression of the Schistosoma-infection. Moreover, the kinetic studies of hepatic ASB in Schistosomainfection showed that a slight decrease in the value of K m and about a 40% increase in V max when compared to the control. In addition, the pH optimum of hepatic ASB was altered from 6 to 7 as a result of schistosomiasis. These observations suggest that there are schistosomiasis-associated changes of the catalytic and kinetic properties of hepatic ASB.

The effect of three species of hypoglycemic herbs (Termis, Halfa barr, or Kammun Quaramany) on the lipid profile was investigated in plasma and liver tissues of diabetic and herbs-treated diabetic rats. This profile includes total lipids (TL), triglycerides (TG), cholesterol, high-density lipoprotein (HDL) and low-density lipoprotein (LDL). A dose of 1.5 ml of aqueous suspension of each herb/100 g body weight (equivalent to 75 mg/100 g body weight) was orally administered daily to alloxan-diabetic rats for four weeks. The present study showed 2-fold increase (p<0.05) in the plasma glucose level of diabetic rats, which received alloxan as a single dose of 120 mg/kg body weight, relative to the mean value of control group. This elevated glucose level was restored to its normal level after treatment with any one of the three herbs. Furthermore, the levels of TL, TG, cholesterol, LDL and VLDL were significantly (p<0.05) increased in the plasma and the liver tissues of diabetic rats compared to the control group, whereas HDL level was significantly (p<0.05) decreased. The plasma levels of all above parameters were normalized after treatment of the diabetic rats with Kammun Quaramany. Treatment of diabetic rats with Tennis normalized TG, cholesterol, LDL and VLDL levels, but Halfa barr restored the induced levels of plasma cholesterol, LDL and HDL to their normal levels. On the other hand, treatment with any of the three herbal suspensions could not restore the concentrations of the all tested parameters in the liver. These data demonstrated that the glycemic control of any of the three herbal suspensions was associated with their hypocholesterolemic effects on the hypercholesterolemia of the alloxan-induced diabetic rats. Moreover, the Kammun Quaramany showed the most potent effect.

The IceWind turbine, a new type of Vertical Axis Wind Turbine, was proposed by an Iceland based startup. It is a product that has been featured in few published scientific research studies. This paper investigates the IceWind turbine’s performance numerically. Three-dimensional numerical simulations are conducted for the full scale model using the SST K-ω model at a wind speed of 15.8 m/s. The following results are documented: static torque, velocity distributions and streamlines, and pressure distribution. Comparisons with previous data are established. Additionally, comparisons with the Savonius wind turbine in the same swept area are conducted to determine how efficient the new type of turbine is. The IceWind turbine shows a similar level of performance with slightly higher static torque values. Vortices behind the IceWind turbine are confirmed to be three-dimensional and are larger than those of Savonius turbine.

Aerodynamics has identified remarkable development in the improvement of fuel efficiency, reducing wind noise and increasing engine cooling. Moving body profile controls fuel the consumption rate. This paper discusses a novel car profile consisting of two airfoils Roncz (car profile) and National Advisory Committee for Aeronautics NACA 10 (car sides). They are used to create a streamlined body. Three-Dimensional numerical simulations of the full scale model (half domain) are performed to examine the effect of car profile on the drag coefficient and thus fuel consumption. Simulations are considered over a range of air flow velocities, from 20 to 45 km/h in a step of 5 km/h. The ahmed body is used to validate the results. Results are shown graphically for coefficients of drag and lift and pressure and velocity contours. They show that the design of the car profile is effective.

Quinazolinone derivatives have been studied as both in vitro and in vivo inhibitors of aspartate transcarbamylase (ATCase). In vitro treatment of mammalian ATCase with four compounds revealed that they inhibited enzyme activity and that 2-phenyl-1,3-4(H)benzothiazin-4-thione was the most potent one. This compound acts as a noncompetitive inhibitor towards both aspartate and carbamoyl phosphate. The values of the inhibition constant (K i) indicate that this compound exerts a potent inhibitory effect upon ATCase activity. Moreover, in vivo treatment with different doses of these derivatives showed also an inhibitory effect upon ATCase, the relative activity being decreased by 40%-58% with a 1 mg dose. These data support the inhibition of ATCase by quinazolinone derivatives as a new type of inhibitor for the enzyme.

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