An artificial bee colony (ABC) is a relatively recent swarm intelligence optimization approach. In this paper, we propose the first attempt at applying ABC algorithm in analyzing a microarray gene expression profile. In addition, we propose an innovative feature selection algorithm, minimum redundancy maximum relevance (mRMR), and combine it with an ABC algorithm, mRMR-ABC, to select informative genes from microarray profile. The new approach is based on a support vector machine (SVM) algorithm to measure the classification accuracy for selected genes. We evaluate the performance of the proposed mRMR-ABC algorithm by conducting extensive experiments on six binary and multiclass gene expression microarray datasets. Furthermore, we compare our proposed mRMR-ABC algorithm with previously known techniques. We reimplemented two of these techniques for the sake of a fair comparison using the same parameters. These two techniques are mRMR when combined with a genetic algorithm (mRMR-GA) and mRMR when combined with a particle swarm optimization algorithm (mRMR-PSO). The experimental results prove that the proposed mRMR-ABC algorithm achieves accurate classification performance using small number of predictive genes when tested using both datasets and compared to previously suggested methods. This shows that mRMR-ABC is a promising approach for solving gene selection and cancer classification problems.
In this paper, we propose apply ABC algorithm in analyzing microarray dataset. In addition, we propose an innovative hybrid classification model, Support Vector Machine (SVM) with ABC algorithm, to measure the classification accuracy for selected genes. We evaluate the performance of the proposed ABC-SVM algorithm by conducting extensive experiments on six binary and multi-class microarrays dataset. Furthermore, we compare our proposed ABC-SVM algorithm with previously known techniques. The experimental results prove that ABC-SVM algorithm is promising approach for solving gene selection and cancer classification problems, and achieves the highest classification accuracy together with the lowest average of selected genes compared to previously suggested methods.
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