Introduction: In Iran, during the years, the budgeting model used for healthcare funding is affected by factors such as global oil prices and fluctuation in the exchange rates, so developing or continuing to implement a plan in the health system depends on the current and future global and local economic trends. This study aimed to analyze the future of the recent significant reform called Health Transformation Plan (HTP), started on 15 Jun 2014 in light of potential financial barriers and challenges.Methods: Face to face interviews were conducted with health policymakers at different levels of the health system, health researchers, health insurance officers, and faculty members. Also, published and unpublished documents about HTP in the country and worldwide were reviewed. Data analysis was done using a qualitative inductive content analysis approach and assisted by qualitative data management software.Findings: Instability of financial resources and allocation of Gross Domestic Product (GDP) to the HTP in the traditional way is a challenge in continuing this policy reform. Also, the bureaucratic procedures in allocation and distribution of funds, discrepancy between health insurance funds and affiliated units of Ministry of Health and Medical Education (MoHME) especially Medical Sciences Universities (MSU), the lack of purchaser–provider split, inappropriate payments and compensation mechanisms, and dependence of MSU on especial revenues are the main challenges that threaten the future of HTP in Iran.Conclusion: Given the current situation, where the country's funding resources are often unpredictable, it seems that such funding challenges will lead to poor HTP results. Therefore, the continuance of such high cost-based plan requires the strategies and policies to ensure raising additional funds through various types of innovative financing to overcome challenges.
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