Sickle cell anemia (SCA) is a serious hematological disorder, where affected patients are frequently hospitalized throughout a lifetime and even can cause death. The manual method of detecting and classifying abnormal cells of SCA patient blood film through a microscope is time-consuming, tedious, prone to error, and require a trained hematologist. The affected patient has many cell shapes that show important biomechanical characteristics. Hence, having an effective way of classifying the abnormalities present in the SCA disease will give a better insight into managing the concerned patient's life. This work proposed algorithm in two-phase firstly, automation of red blood cells (RBCs) extraction to identify the RBC region of interest (ROI) from the patient’s blood smear image. Secondly, deep learning AlexNet model is employed to classify and predict the abnormalities presence in SCA patients. The study was performed with (over 9,000 single RBC images) taken from 130 SCA patient each class having 750 cells. To develop a shape factor quantification and general multiscale shape analysis. We reveal that the proposed framework can classify 15 types of RBC shapes including normal in an automated manner with a deep AlexNet transfer learning model. The cell's name classification prediction accuracy, sensitivity, specificity, and precision of 95.92%, 77%, 98.82%, and 90% were achieved, respectively.
<p>In medical field, the recognition of red blood cells (RBC) are used as an indicator to detect the type of diseases such as anaemia, malaria and leukaemia etc. The problems using manual detection of normal and abnormal RBCs under the microscope is tend to give inaccurate result and errors. This paper proposed a method to recognize the normal and abnormal shaped RBCs image by using Form Factor as feature descriptor. Detecting normal cells of RBCs indicate a healthy patient and abnormal cells indicate presence of disease. And is very important in medical field to detect abnormal condition in early stage because it saves and protects human lives. The patients waiting time for blood test is more because the time taking to generate the result of the patient is high due to high demand and less equipment this method is used in order to improve the accuracy of the existing one and 94% accuracy was achieved in the detection.</p>
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