: Introduction: The performance of “en-face” optical coherence tomography (OCT) in screening for chloroquine (CQ) or hydroxychloroquine (HCQ) retinopathy has not been largely explored. The aim of this study was to determine the concordance of “en-face” OCT with multifocal electroretinography (mfERG) in screening for CQ/HCQ retinopathy. Methods: This is a prospective cohort study conducted at the Rothschild Foundation Hospital – Paris between August 2016 and February 2021. Patients taking hydroxychloroquine were followed up over 2 consecutive years and received an “en-face” OCT and a mfERG on each visit. Results: A total of 91 patients (182 eyes) were analyzed. mfERG and “en-face” OCT were concordant in 147 eyes (86.3%). Cohen’s Kappa coefficient for concordance between mfERG and “en-face” OCT was considered weak with a value 0.61 (95% CI: 0.50-0.72). The sensitivity and specificity of “en-face” OCT are 70% (95% CI: 59-79%) and 91% (95% CI: 83-96%) respectively, relatively to mfERG. Proportion of abnormal R2/R5 and R3/R5 ratios did not differ between patients with normal and abnormal “en-face” OCT (p=0.2). Discussion/Conclusion: “En-face” OCT and mfERG have low concordance and cannot be used interchangeably as each investigation evaluates a different facet of CQ/HCQ retinopathy. “En-face” OCT could be used as a complement in screening for CQ/HCQ retinal toxicity if the anomalies detected on “en-face” OCT are confirmed by B-scan OCT sections.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.