Resveratrol, a natural phenolic compound, provides neuroprotective effects, however, the specific mechanisms of action remain to be elucidated. The purpose of the present study was to examine the neuroprotective effect of resveratrol on spinal cord injury (SCI) and the potential molecular mechanisms of action. A rat model of SCI was induced using Allen's method, and resveratrol (100 mg/kg) was intraperitoneally injected 1 day following surgery. The recovery of neurological function was assessed using the Basso, Beattie, Bresnahan scoring system and an inclined plane test. The concentrations of pro‑ and anti‑inflammatory factors were measured using ELISA. The expression and location of autophagy markers were measured using western blot and immunofluorescence analyses. The results suggested that resveratrol administration resulted in functional improvement of locomotor activity and reduced neuroinflammation following the induction of SCI. In addition, autophagy was activated following SCI, as demonstrated by the significantly increased ratio of microtubule‑associated protein light chain 3 (LC3)‑II/LC3‑I and expression of Beclin‑1 in the injured spinal cord. Of note, the enhancement of phosphorylated (p)‑AMP‑activated protein kinase (AMPK) and the reduction of p‑mammalian target of rapamycin (mTOR) following SCI indicated that the SCI‑induced activation of autophagy was associated with the AMPK/mTOR signaling pathway. Resveratrol treatment further enhanced the activation of autophagy via the AMPK/mTOR pathway following SCI. By contrast, the autophagic inhibitor, 3‑methyladenine, partially inhibited the neuroprotective effects of resveratrol treatment. Together, these findings suggested that resveratrol promoted functional recovery and inhibited neuroinflammation through the activation of autophagy mediated by the AMPK/mTOR pathway following SCI.
BACKGROUND: To study the effect of the positional relationship between the position of the opening within the tibial tunnel and the extension of the parietal line of the intercondylar fossa on early graft rupture after ACLR. METHODS: Patients were divided into three groups A, B, and C according to the positional relationship between the extension of the top line of the intercondylar fossa of the femur and the opening within the tibial tunnel, and risk factors related to the relationship between their age, sex, graft diameter, BMI, and graft survival of the affected knee and its position were analyzed and compared. RESULTS: The age, BMI, and gender of the patients in the three groups were not statistically significant; the mean graft diameter of the patients in the three groups was statistically significant, and the mean graft diameter size was statistically different between group A and group C, and between group B and group C. The mean graft diameter in group C was larger than that in groups A and B; the graft survival rate of the patients in the three groups was statistically significant, and the graft survival rate in groups A and C was higher than that in group B. Conclusion: The more posterior the position of the extension line of the top line of the intercondylar fossa intersecting the inner exit of the tibial tunnel, the more serious the impingement of the femoral intercondylar fossa with the graft, and the higher the early graft rupture rate after the reconstruction of the anterior cruciate ligament; It is not that the larger the graft diameter, the lower the graft rupture rate; the most effective measure to avoid early graft rupture is a reasonable tibial tunnel position to avoid the impingement on the graft.
Unicompartmental knee arthroplasty (UKA) is one of the commonly used surgical methods for unicompartmental osteoarthritis in recent years. Although the prognosis of the operated knee has been widely studied, there are relatively little data on the natural history of the contralateral knee after unilateral replacement. The aim of this study was to explore the incidence and risk factors of consequential knee arthroplasty in patients with bilateral knee osteoarthritis (KOA) after receiving primary unilateral UKA, so as to provide a theoretical basis for making a more comprehensive treatment strategy for patients with KOA. We conducted a retrospective study and enrolled patients with bilateral KOA received unilateral UKA from June 2015 to December 2019 in the third department of joint orthopedics, the third hospital of Hebei Medical University. The patients were divided into replacement group and non-replacement group according to whether the contralateral knee joint received knee arthroplasty. Information about treatment of contralateral knee joint was collected from medical records to determine the incidence. Univariate analysis and multivariate logistic regression analysis were performed to identify the independent risk factors. A total of 502 patients were enrolled in this study. The incidence of contralateral knee arthroplasty was 38.64%. In the univariate analysis, vertical angle of mechanical axis, knee joint's internal and external joint space, Kellgren–Lawrence (K-L) classification, femoral tibial angle were the significant risk factors for contralateral knee arthroplasty. In the multivariate model, only vertical angle of mechanical axis ≥3.03° (odds ratio [OR] 4.36, 95% confidence interval [CI], 2.47–9.11), K-L classification grades 3 and 4 (OR 2.46,3.72; 95%CI, 1.31–4.25, 1.98–6.87), and femoral tibial angle ≥187.32° (OR 6.32, 95%, 2.23–18.87) remained associated with the occurrence of knee arthroplasty. About a quarter of patients with bilateral KOA received unilateral UKA will receive contralateral knee arthroplasty. Higher K-L classification, femoral tibial angle, and mechanical axis vertical angle are identified risk factors.
Background: This retrospective study introduced an alternative treatment of types A2, A3, and B1 distal radius fractures using percutaneous pinning with cemented K-wire frame. Methods: From January 2017 to January 2020, 78 patients with distal radius fractures were treated with percutaneous pinning and cemented K-wire frame. There were 14 male patients and 4 female patients. There were types A2 (n=10), A3 (n=46), and B1 (n=22) fractures. X-rays were taken immediately after surgery and after bone healing. Wrist function was assessed with Mayo Wrist Score to assess wrist function (90–100, excellent; 80–90, good; 60–80, satisfactory; below 60, poor). Patient satisfaction on the upper limb was assessed using the 10-cm visual analog scale. Results: The data showed the fragments were kept in place without significant redisplacment (P>0.05). No wire loosening was found. All K-wires were kept in place without bone lessening. Fixation failure or osteomyelitis was not observed in this series. Bone healing was achieved in all patients at a mean of 4.5 months (range, 4 to 8 months). Follow-ups lasted for a mean of 27 months (range, 24 to 33 months). The mean score of wrist function was 97 (range, 91 to 100), including 66 excellent and 12 good results. The mean patient satisfaction was 10 cm (range, 8 to 10 cm).Conclusions: Percutaneous pinning with cemented K-wire frame is a safe and preferred choice for the treatment of types A2, A3, and B1 distal radius fractures. The frame provides support to prevent wire migration. The fixation is a minimally invasive technique that is easy to perform. Level of Evidence: Therapeutic study, Level IVa.
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