Background: Cullin-RING ubiquitin ligases are the largest family of E3 ligases, but their roles in ovarian cancers remain uninvestigated. Results: Inhibition of CRL4 activity induced ovarian cancer death. Conclusion: CRL4CDT2 repression and CDT1 accumulation contributed to the genotoxic effects of MLN4924 in ovarian cancer cells. Significance: Indicating CRL4CDT2 is an effective drug target in ovarian cancers.

A Large number of digital text information is

Text classification algorithms, such SVM, and Naïve Bayes, have been developed to build up search engines and construct spam email filters. As a simple yet powerful sample of Bayesian Theorem, Naïve Bayes shows advantages in text classification yielding satisfactory results. In this paper, a spam email detector is developed using Naïve Bayes algorithm. We use pre-classified emails (priory knowledge) to train the spam email detector. With the model generated from the training step, the detector is able to decide whether an email is a spam email or an ordinary email.2007 IEEE International Conference on Granular Computing 0-7695-3032-X/07 $25.00

No abstract

Glucocorticoids (GCs) are essential for mouse embryo implantation and decidualization. Excess GCs are harmful for mouse embryo implantation and decidualization. 11β-Hydroxysteroid dehydrogenases type I and II (Hsd11b1/Hsd11b2) are main enzymes for regulating local level of GCs. Hsd11b2 acts as the placental glucocorticoid barrier to protect the fetus from excessive exposure. Although effects of GCs on the fetus and placenta in late pregnancy have been extensively studied, the effects of these adrenal corticosteroids in early pregnancy are far less well defined. Therefore, we examined the expression, regulation and function of Hsd11b1/Hsd11b2 in mouse uterus during early pregnancy. We found that Hsd11b2 is highly expressed in endometrial stromal cells on days 3 and 4 of pregnancy and mainly upregulated by progesterone (P4). In both ovariectomized mice and cultured stromal cells, P4 significantly stimulates Hsd11b2 expression. P4 stimulation of Hsd11b2 is mainly mediated by the Ihh pathway. The uterine level of corticosterone (Cort) is regulated by Hsd11b2 during preimplantation. Embryo development and the number of inner cell mass cells are suppressed by Cort treatment. These results indicate that P4 should provide a low Cort environment for the development of preimplantation mouse embryos by promoting the expression of uterine Hsd11b2.