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Recent developments in the field of artificial intelligence and data analytics are facilitating the automation of some consumer chores (e.g., in smart homes and in self-driving cars) and allow the emergence of big-data-driven, micro-targeting marketing practices (e.g., personalized content recommendation algorithms). We contend that those developments can generate a tension for marketers, consumers, and policy makers: They can, on the one hand, contribute to consumer well-being by making consumer choices easier, more practical, and more efficient. On the other hand, they can also undermine consumers' sense of autonomy, the absence of which can be detrimental to consumer well-being. Drawing on diverse perspectives from marketing, economics, philosophy, neuroscience, and psychology, we explore how consumers' sense of autonomy in making choices affects their wellbeing. We discuss how new technologies may enhance or diminish consumers' perceptions of being in control of their choices and how either of those can, in turn, enhance of detract from consumer well-being. Building on this, we identify open research questions in the domain of choice, well-being, and consumer welfare, and suggest avenues for future research.

The association of DSIF and NELF with initiated RNA Polymerase II (Pol II) is the general mechanism for inducing promoter-proximal pausing of Pol II. However, it remains largely unclear how the paused Pol II is released in response to stimulation. Here, we show that the release of the paused Pol II is cooperatively regulated by multiple P-TEFbs which are recruited by bromodomain-containing protein Brd4 and super elongation complex (SEC) via different recruitment mechanisms. Upon stimulation, Brd4 recruits P-TEFb to Spt5/DSIF via a recruitment pathway consisting of Med1, Med23 and Tat-SF1, whereas SEC recruits P-TEFb to NELF-A and NELF-E via Paf1c and Med26, respectively. P-TEFb-mediated phosphorylation of Spt5, NELF-A and NELF-E results in the dissociation of NELF from Pol II, thereby transiting transcription from pausing to elongation. Additionally, we demonstrate that P-TEFb-mediated Ser2 phosphorylation of Pol II is dispensable for pause release. Therefore, our studies reveal a co-regulatory mechanism of Brd4 and SEC in modulating the transcriptional pause release by recruiting multiple P-TEFbs via a Mediator- and Paf1c-coordinated recruitment network.

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A novel ferric-phosphate induced shape memory (SM) hydrogel is prepared by the one-step copolymerization of isopropenyl phosphonic acid (IPPA) and acrylamide (AM) in the presence of a crosslinker polyethylene glycol diacrylate (PEGDA). Different from the traditional SM hydrogels, our SM hydrogel can be processed into various shapes as needed and recovers to its original form in ‘multiconditions’ such as in the presence of a reducing agent or in the presence of a competitive complexing agent. This unique feature is attributed to the fact that the oxidized ferric ions show a high complexation ability with phosphate groups of IPPA, which acts as a physical crosslinker to form the secondary networks within the hydrogels to induce the shape memory effect. The memory behavior was totally reversible, owing to Fe3+ that can be reduced to Fe2+ and extracted by the complexing agent. Particularly, the SM hydrogels exhibit controllable and good mechanical characteristics by introduction of the ferric ions, i.e., the elastic modulus can increase from 2 kPa to 70 kPa dramatically. Learning from biological systems, phosphate-metal ion based hydrogels could become an attractive candidate for various biomedical and environmental applications.

Five studies using a variety of experimental approaches and secondary data sets show that a visual property present in all brand logos—the degree of (a)symmetry—can interact with brand personality to affect brand equity. Specifically, compared with symmetrical logos, asymmetrical logos tend to be more arousing, leading to increased perceptions of excitement. As such, consumers tend to perceive asymmetrical logos as more congruent with brands that have an exciting personality. This can boost consumers’ evaluations and the market’s financial valuations of such brands, a phenomenon referred to as the “visual asymmetry effect.” The studies also show that this interplay between brand personality and logo design occurs only for the personality of excitement and the visual property of asymmetry. These findings add to theories of visual design and branding and offer actionable insights to marketing practitioners.

An injectable thermo-responsive hydrogel with excellent mechanical properties which can self-heal under mildly acidic to basic conditions was prepared.

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