No abstract

To investigate the coadsorption of SO 2 , NO, and CO 2 from the flue gas, adsorption equilibrium tests of SO 2 , NO, and CO 2 on coconut shell activated carbon (SAC) and coal-based activated carbon (CAC) were conducted at the temperatures (323, 343, and 363) K by the static volumetric method. The equilibrium data were well fitted by the Toth model. Henry's constant was calculated by the Virial model; the results showed that adsorption affinity followed the order SO 2 > CO 2 > NO > N 2 on SAC, and SO 2 > NO > CO 2 > N 2 on CAC. Then thermodynamics data, including Gibbs' free energy, entropy, and enthalpy, were also calculated to characterize adsorption behaviors. SO 2 had the highest degree of freedom, while CO 2 formed a most regular configuration. The efficiency of molecule packing in CAC was lower than that in SAC. Finally, competitive adsorption of different flue gas components was predicted by the extended Toth model. The adsorption amount followed the order CO 2 > N 2 > SO 2 > NO for both adsorbents. SAC had better adsorption property than CAC in the multicomponent adsorption.

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Nowadays, chemotherapy is one of the principal modes of treatment for tumor patients. However, the traditional formulations of small molecule drugs show short circulation time, low tumor selectivity, and high toxicity to normal tissues. To address these problems, a facilely prepared, and pH and reduction dual-responsive polypeptide nanogel was prepared for selectively intracellular delivery of chemotherapy drug. As a model drug, doxorubicin (DOX) was loaded into the nanogel through a sequential dispersion and dialysis technique, resulting in a high drug loading efficiency (DLE) of 96.7 wt.%. The loading nanogel, defined as NG/DOX, exhibited a uniform spherical morphology with a mean hydrodynamic radius of 58.8 nm, pH and reduction dual-triggered DOX release, efficient cell uptake, and cell proliferation inhibition in vitro. Moreover, NG/DOX exhibited improved antitumor efficacy toward H22 hepatoma-bearing BALB/c mouse model compared with free DOX·HCl. Histopathological and immunohistochemical analyses were implemented to further confirm the tumor suppression activity of NG/DOX. Furthermore, the variations of body weight, histopathological morphology, bone marrow cell micronucleus rate, and white blood cell count verified that NG/DOX showed excellent safety in vivo. With these excellent properties in vitro and in vivo, the pH and reduction dual-responsive polypeptide nanogel exhibits great potential for on-demand intracellular delivery of antitumor drug, and holds good prospect for future clinical application.

We have located the structures of putative global minima for Morse clusters as a function of the range of the potential and the cluster size (with atom number 161 < or = N < or = 240) using the dynamic lattice searching method. Our work indicates that with the range of the potential decreased, the structure of global minimum changes from disordered to icosahedral to decahedral to close-packed, and meanwhile the size effect on structures becomes weaker. At the middle range of potential, the icosahedral structures with Mackay overlayers are more predominant than those with anti-Mackay overlayers. The conformational analysis of M(200) at different rho(0) is given to get the funnel information of the energy landscape. The energy sequences of global minima at different rho(0) are studied to find out the magic numbers, and the zero temperature "phase diagram" is given for an overall view of how the global minima depend upon N and rho(0).