Objective Hyperhomocysteinemia (HHcy) is considered to increase the risk of sarcopenia (S) and remains controversial. In this study, we aimed to investigate the prevalence of S among older Chinese adults and explore whether homocysteine (Hcy) was independently associated with S. Methods This cross-sectional study was performed among older adults hospitalized in the Geriatric Hospital of Nanjing Medical University between June 2017 and December 2021. We measured all participants’ serum Hcy levels, hand grip strength, gait speed and appendicular skeletal muscle index(ASMI) using bioelectrical impedance analysis (BIA). S was defined based on the criteria of the Asian Working Group for Sarcopenia 2 (AWGS2), which included muscle mass (ASMI< 7.0 kg/m2 for men and ASMI< 5.7 kg/m2 for women by BIA) and low muscle strength (handgrip strength < 28 kg for men and < 18 kg for women), and/or gait speed < 1.0 m/s. HHcy defined as Hcy ≥10 μmol/L. The strength of the association between Hcy and the risk of S was analyzed by multivariate logistic regression using three models that adjusted for possible confounding variables to calculate the odds ratios (ORs) and 95% confidence intervals (CIs). Results Among the 441 subjects, 161 (36.5%) were diagnosed with S, and 343 (77.8%) were diagnosed with HHcy. A significant association was detected between S and serum Hcy per 1-μmol/L increase after adjustment for age, gender, education, smoking, body mass index (BMI), Mini Nutritional Assessment Short Form (MNA-SF), alanine aminotransferase (ALT), C-reactive protein (CRP), hemoglobin (Hb), albumin (ALB), diabetes, kidney disease, and statin use (OR = 1.07, 95% CI = 1.03–1.12, P = 0.002). The OR for S in the HHcy group (≥10 μmol/L) was nearly 5-fold that in the normal Hcy group (OR 4.96, 95% CI 2.67–9.24, P < 0.001). In a gender-based subgroup analysis that adjusted for age, education, smoking, BMI, MNA-SF, ALT, CRP, Hb, and ALB, female subjects with HHcy had an increased risk of S (OR 10.35, 95% CI 2.84–37.68, P < 0.001). Conclusions Our results demonstrated that elevated Hcy levels have an independent association with S in older adults. This suggests that the downward adjustment of HHcy (cutoff value < 10 μmol/l) might decrease the risk of S.
Objection: Hyperhomocysteine (HHcy) is considered to increase the risk of Sarcopenia (SA) and remains controversial. In this study, we aimed to evaluate the association between homocysteine (Hcy) and SA in the Chinese elderly population. Methods: A cross-sectional study of 441 elderly patients, who underwent the measurements of muscle mass, muscle strength, physical performance, and serum Hcy from 2017 to 2021 at Geriatric Hospital of Nanjing Medical University, was carried out to assess the relationship between SA and Hcy. All baseline characteristics and laboratory examination of subjects were collected and analyzed by specific personnel. The strength of association between Hcy and the risk of SA was analyzed by multivariate logistic regression to calculate the odds ratios (ORs) and 95% confidence interval (CI). Results: Among the 441 subjects, 161 (36.51%) cases were diagnosed as SA, and 343 of them were found with HHcy. A significant association was detected between SA and serum Hcy per 1μmol/L increase(adjusted OR = 1.068, 95% CI = 1.021–1.117, p =0.004). In a gender-based subgroup analysis, the subjects with HHcy had an increased risk of SA in female group (adjusted OR 1.098, 95%CI 1.009–1.197, p = 0.036), but not in males. Furthermore, HHcy had a significantly positively associated with SA in the very elderly whose age was more than or equal to 85 (adjusted OR = 1.112, 95% CI = 1.037–1.193, P = 0.003).Conclusions: Hcy has a positive association with SA in Chinese urban population, especially in the elderly females. That suggests a hypothesis that the downward adjustment of Hcy might decrease the risk of SA.
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