Bipolar disorder (BPD) is often confused with major depression, and current diagnostic questionnaires are subjective and time intensive. The aim of this study was to develop a new Bipolar Diagnosis Checklist in Chinese (BDCC) by using machine learning to shorten the Affective Disorder Evaluation scale (ADE) based on an analysis of registered Chinese multisite cohort data. In order to evaluate the importance of each item of the ADE, a case-control study of 360 bipolar disorder (BPD) patients, 255 major depressive disorder (MDD) patients and 228 healthy (no psychiatric diagnosis) controls (HCs) was conducted, spanning 9 Chinese health facilities participating in the Comprehensive Assessment and Follow-up Descriptive Study on Bipolar Disorder (CAFÉ-BD). The BDCC was formed by selected items from the ADE according to their importance as calculated by a random forest machine learning algorithm. Five classical machine learning algorithms, namely, a random forest algorithm, support vector regression (SVR), the least absolute shrinkage and selection operator (LASSO), linear discriminant analysis (LDA) and logistic regression, were used to retrospectively analyze the aforementioned cohort data to shorten the ADE. Regarding the area under the receiver operating characteristic (ROC) curve (AUC), the BDCC had high AUCs of 0.948, 0.921, and 0.923 for the diagnosis of MDD, BPD, and HC, respectively, despite containing only 15% (17/113) of the items from the ADE. Traditional scales can be shortened using machine learning analysis. By shortening the ADE using a random forest algorithm, we generated the BDCC, which can be more easily applied in clinical practice to effectively enhance both BPD and MDD diagnosis.
Recent studies have shown that the feasibility of speech brain-computer interfaces (BCIs) as a clinically valid treatment in helping nontonal language patients with communication disorders restore their speech ability. However, tonal language speech BCI is challenging because additional precise control of laryngeal movements to produce lexical tones is required. Thus, the model should emphasize the features from the tonal-related cortex. Here, we designed a modularized multistream neural network that directly synthesizes tonal language speech from intracranial recordings. The network decoded lexical tones and base syllables independently via parallel streams of neural network modules inspired by neuroscience findings. The speech was synthesized by combining tonal syllable labels with nondiscriminant speech neural activity. Compared to commonly used baseline models, our proposed models achieved higher performance with modest training data and computational costs. These findings raise a potential strategy for approaching tonal language speech restoration.
The brain function of prediction is fundamental for human beings to shape perceptions efficiently and successively. Through decades of effort, a valuable brain activation map has been obtained for prediction. However, much less is known about how the brain manages the prediction process over time using traditional neuropsychological paradigms. Here, we implemented an innovative paradigm for timing prediction to precisely study the temporal dynamics of neural oscillations. In the experiment recruiting 45 participants, expectation suppression was found for the overall electroencephalographic activity, consistent with previous hemodynamic studies. Notably, we found that N1 was positively associated with predictability while N2 showed a reversed relation to predictability. Furthermore, the matching prediction had a similar profile with no timing prediction, both showing an almost saturated N1 and an absence of N2. The results indicate that the N1 process showed a 'sharpening' effect for predictable inputs, while the N2 process showed a 'dampening' effect. Therefore, these two paradoxical neural effects of prediction, which have provoked wide confusion in accounting for expectation suppression, actually co-exist in the procedure of timing prediction but work in separate time windows. These findings strongly support a recently-proposed opposing process theory.
Purpose Dynamic positron emission tomography (PET) is known for its ability to extract spatiotemporal information of a radio tracer in living tissue. Information of different functional regions based on an accurate reconstruction of the activity images and kinetic parametric images has been widely studied and can be useful in research and clinical setting for diagnosis and other quantitative tasks. In this paper, our purpose is to present a novel framework for estimating the kinetic parametric images directly from the raw measurement data together with a simultaneous segmentation accomplished through kinetic parameters clustering. Method An iterative framework is proposed to estimate the kinetic parameter image, activity map and do the segmentation simultaneously from the complete dynamic PET projection data. The clustering process is applied to the kinetic parameter variable rather than to the traditional activity distribution so as to achieve accurate discrimination between different functional areas. Prior information such as total variation regularization is incorporated to reduce the noise in the PET images and a sparseness constraint is integrated to guarantee the solution for kinetic parameters due to the over complete dictionary. Alternating direction method of multipliers (ADMM) method is used to solve the optimization problem. The proposed algorithm was validated with experiments on Monte Carlo‐simulated phantoms and real patient data. Symbol error rate (SER) was defined to evaluate the performance of clustering. Bias and variance of the reconstruction activity images were calculated based on ground truth. Relative mean square error (MSE) was used to evaluate parametric results quantitatively. Result In brain phantom experiment, when counting rate is 1 × 106, the bias (variance) of our method is 0.1270 (0.0281), which is lower than maximum likelihood expectation maximization (MLEM) 0.1637 (0.0410) and direct estimation without segmentation (DE) 0.1511 (0.0326). In the Zubal phantom experiment, our method has the lowest bias (variance) 0.1559 (0.0354) with 1 × 105 counting rate, compared with DE 0.1820 (0.0435) and MLEM 0.3043 (0.0644). As for classification, the SER of our method is 18.87% which is the lowest among MLEM + k‐means, DE + k‐means, and kinetic spectral clustering (KSC). Brain data with MR reference and real patient results also show that the proposed method can get images with clear structure by visual inspection. Conclusion In this paper, we presented a joint reconstruction framework for simultaneously estimating the activity distribution, parametric images, and parameter‐based segmentation of the ROIs into different functional areas. Total variation regularization is performed on the activity distribution domain to suppress noise and preserve the edges between ROIs. An over complete dictionary for time activity curve basis is constructed. SER, bias, variance, and MSE were calculated to show the effectiveness of the proposed method.
Dynamic positron emission tomography (PET) is capable of providing both spatial and temporal information of radio tracers in vivo. In this paper, we present a novel joint estimation framework to reconstruct temporal sequences of dynamic PET images and the coefficients characterizing the system impulse response function, from which the associated parametric images of the system macro parameters for tracer kinetics can be estimated. The proposed algorithm, which combines statistical data measurement and tracer kinetic models, integrates a dictionary sparse coding (DSC) into a total variational minimization based algorithm for simultaneous reconstruction of the activity distribution and parametric map from measured emission sinograms. DSC, based on the compartmental theory, provides biologically meaningful regularization, and total variation regularization is incorporated to provide edge-preserving guidance. We rely on techniques from minimization algorithms (the alternating direction method of multipliers) to first generate the estimated activity distributions with sub-optimal kinetic parameter estimates, and then recover the parametric maps given these activity estimates. These coupled iterative steps are repeated as necessary until convergence. Experiments with synthetic, Monte Carlo generated data, and real patient data have been conducted, and the results are very promising.
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