In this study, the Weather Research and Forecasting model was coupled with an improved Noah land surface model (WRF‐Noah) where dynamic flood and drip irrigation processes were implemented firstly. We simulated the different irrigation effects on surface water‐heat processes in a typical mountain‐oasis‐desert system in Central Asia for both wet and drought years, respectively, using the modified WRF‐Noah. The modified WRF‐Noah model can dynamically generate amounts of irrigation in agreement with actual values. The statistically significant decrease in the root mean square error and increase in the Pearson correlation coefficient for the 2‐m temperature (T2), relative humidity (RH), latent heat flux (LE), and precipitation suggest that the modified WRF‐Noah model was improved by implementing irrigation processes. During the irrigation season, flood and drip irrigation decreased the average sensible heat flux by −80.69 and −50.50 W/m2 and T2 by 1.09 and 0.82 °C over the irrigated area and increased LE by 88.47 and 66.70 W/m2 and RH by 6.23% and 4.65%, respectively. Throughout the domain, flood irrigation had equivalent or slightly weaker effects on near‐surface temperature and humidity due to the smaller irrigated area. Both flood and drip irrigation increased precipitation throughout the domain, especially in the mountainous area, thereby accelerating the hydrological cycle in the mountain‐oasis‐desert system. The local oasis breeze circulation that plays a role in maintaining the oasis stability is still counteracted by the dominant background circulation even with irrigation processes. Thus, more effort should be exerted to maintain the future sustainability of the oasis.

A series of novel benzoxazinyl-oxazolidinones bearing nonaromatic heterocycle or aryl groups were designed and synthesized. Their in vitro and in vivo antibacterial activities were investigated. Most of the (3S, 3aS) biaryl benzoxazinyl-oxazolidinones exhibited potent activity against Gram-positive pathogens. SAR trends were observed; a pyridyl C ring was preferable to other 5- or 6-member aryl C rings, while fluorine substitution on the B ring generated derivatives with reduced activity. Various substituent group positions on the pyridyl ring were also evaluated. The resulting compounds displayed excellent activity against linezolid-resistant strains. Compound 45 exhibited excellent in vitro activity, with a MIC value of 0.25-0.5 μg/mL against MRSA and an activity against linezolid-resistant strains of 8-16-fold higher potency than linezolid. In a MRSA systemic infection model, compound 45 displayed an ED(50) < 5.0 mg/kg, a potency that is nearly 3-fold better than that of linezolid. This compound also showed excellent pharmacokinetic profiles, with a half-life of more than 5 h as well as an oral bioavailability of 81% in rats.

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Ion energy distributions (IEDs), electron energy distributions (EEDs) and other plasma parameters of magnetron sputtering discharges driven by 13.56, 27.12 and 60 MHz sources were investigated by a retarding field energy analyzer and Langmuir probe measurements. An increase in driving frequency leads to an increase in ion energy and the evolution of IEDs from a uni-modal distribution at the 13.56 MHz discharge toward a bi-modal distribution at 27.12 MHz, and a multi-modal distribution at the 60 MHz discharge. For IEDs near the target surface, this evolution is related to the ion acceleration and the charge transfer collisions between Ar atoms and Ar + ions in the presheath, while for IEDs at the substrate, the evolution depends on the ratio of the ion transit time across the sheath to the radio frequency period. The increase in driving frequency also leads to the evolution of EED function from a Maxwellian type at the 13.56 MHz discharge toward a bi-Maxwellian type at the 27.12 MHz discharge and a Druyvesteyn-like type at the 60 MHz discharge due to the change in the generation and loss mechanisms of electrons. In addition, increasing the driving frequency can lead to a higher electron temperature and a lower electron density. Therefore, the driving frequency becomes an effective tool to control the plasma properties of magnetron sputtering discharges.

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As an effect of climate change, cities need detailed information on urban climates at decision scale that cannot be easily delivered using current observation networks, nor global and even regional climate models. A review is presented of the recent literature and recommendations are formulated for future work. In most cities, historical observational records are too short, discontinuous, or of too poor quality to support trend analysis and climate change attribution. For climate modeling, on the other hand, specific dynamical and thermal parameterization dedicated to the exchange of water and energy between the atmosphere and the urban surfaces have to be implemented. Therefore, to fully understand how cities are impacted by climate change, it is important to have (1) simulations of the urban climate at fine spatial scales (including coastal hazards for coastal cities) integrating global climate scenarios with urban expansion and population growth scenarios and their associated uncertainty estimates, (2) urban climate observations, especially in Global South cities, and (3) spatial data of high resolution on urban structure and form, human behavior, and energy consumption.

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