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Limited biomarkers have been identified as prognostic predictors for stage III colon cancer. To combat this shortfall, we developed a computer-aided approach which combing convolutional neural network with machine classifier to predict the prognosis of stage III colon cancer from routinely haematoxylin and eosin (H&E) stained tissue slides. We trained the model by using 101 cancers from West China Hospital (WCH). The predictive effectivity of the model was validated by using 67 cancers from WCH and 47 cancers from The Cancer Genome Atlas Colon Adenocarcinoma database. The selected model (Gradient Boosting-Colon) provided a hazard ratio (HR) for high- vs. low-risk recurrence of 8.976 (95% confidence interval (CI), 2.824–28.528; P, 0.000), and 10.273 (95% CI, 2.177–48.472; P, 0.003) in the two test groups, from the multivariate Cox proportional hazards analysis. It gave a HR value of 10.687(95% CI, 2.908–39.272; P, 0.001) and 5.033 (95% CI,1.792–14.132; P, 0.002) for the poor vs. good prognosis groups. Gradient Boosting-Colon is an independent machine prognostic predictor which allows stratification of stage III colon cancer into high- and low-risk recurrence groups, and poor and good prognosis groups directly from the H&E tissue slides. Our findings could provide crucial information to aid treatment planning during stage III colon cancer.

BackgroundAn intracranial aneurysm is a cerebrovascular disorder that can result in various diseases. Clinically, diagnosis of an intracranial aneurysm utilizes digital subtraction angiography (DSA) modality as gold standard. The existing automatic computer-aided diagnosis (CAD) research studies with DSA modality were based on classical digital image processing (DIP) methods. However, the classical feature extraction methods were badly hampered by complex vascular distribution, and the sliding window methods were time-consuming during searching and feature extraction. Therefore, developing an accurate and efficient CAD method to detect intracranial aneurysms on DSA images is a meaningful task.MethodsIn this study, we proposed a two-stage convolutional neural network (CNN) architecture to automatically detect intracranial aneurysms on 2D-DSA images. In region localization stage (RLS), our detection system can locate a specific region to reduce the interference of the other regions. Then, in aneurysm detection stage (ADS), the detector could combine the information of frontal and lateral angiographic view to identify intracranial aneurysms, with a false-positive suppression algorithm.ResultsOur study was experimented on posterior communicating artery (PCoA) region of internal carotid artery (ICA). The data set contained 241 subjects for model training, and 40 prospectively collected subjects for testing. Compared with the classical DIP method which had an accuracy of 62.5% and an area under curve (AUC) of 0.69, the proposed architecture could achieve accuracy of 93.5% and the AUC of 0.942. In addition, the detection time cost of our method was about 0.569 s, which was one hundred times faster than the classical DIP method of 62.546 s.ConclusionThe results illustrated that our proposed two-stage CNN-based architecture was more accurate and faster compared with the existing research studies of classical DIP methods. Overall, our study is a demonstration that it is feasible to assist physicians to detect intracranial aneurysm on DSA images using CNN.

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As an essential requirement of pervasive smart devices, free hand gestural input considered as necessary for user interactions has attracted lots of research attention for nearly decades. Nevertheless, existing proposals heavily rely on either expensive pre-deployed equipment or user on-body sensors, thus confine their application scenarios. In this paper, we propose a novel hand gesture recognition system which purely relies on ubiquitous ambient light and low-cost photodiodes. The proposed system does not need any modification to existing lighting infrastructure. While without complex signal pre-processing for modulated light, very low-cost photodiodes and processors can capture and process the light variations caused by hand gesture. To produce accurate hand gesture recognition, we design efficient algorithms based on recurrent neural network to process sensing data collected by a photodiode array. We implement a prototype consisting of an array of 8 photodiodes and extensive experiments demonstrate that the proposed solution can achieve a very high overall recognition accuracy of 99.31%. INDEX TERMS Visible light sensing, recurrent neural network, hand gesture recognition.

Videos have become the new preference comparing with images in recent years. However, during the recording of videos, the cameras are inevitably occluded by some objects or persons that pass through the cameras, which would highly increase the workload of video editors for searching out such occlusions. In this paper, for releasing the burden of video editors, a frame-level video occlusion detection method is proposed, which is a fundamental component of automatic video editing. The proposed method enhances the extraction of spatial-temporal information based on C3D yet only using around half amount of parameters, with an occlusion correction algorithm for correcting the prediction results. In addition, a novel loss function is proposed to better extract the characterization of occlusion and improve the detection performance. For performance evaluation, this paper builds a new large scale dataset, containing 1,000 video segments from seven different real-world scenarios, which could be available at: https://junhua-liao.github.io/Occlusion-Detection/. All occlusions in video segments are annotated frame by frame with bounding-boxes so that the dataset could be utilized in both frame-level occlusion detection and precise occlusion location. The experimental results illustrate that the proposed method could achieve good performance on video occlusion detection compared with the state-of-the-art approaches. To the best of our knowledge, * Both authors contributed equally to this research.

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