The aim of the study was to estimate the prognostic and clinicopathologic significance of miR-125a-5p in human cancers. Eligible studies were obtained from PubMed, Embase, and the Cochrane Library. Combined hazard ratios (HRs) and odds ratios (ORs) were used to evaluate the prognostic and clinicopathologic value of miR-125a-5p. In pan-cancer, high miR-125a-5p expression was associated with better overall survival (OS) (HR = 0.459, 95% confidence interval [CI]: 0.369–0.57, P < .001), and disease-free survival (HR = 0.343, 95% CI: 0.237–0.496, P < .001). Furthermore, favorable OS was also found in lung cancer (HR = 0.343, 95% CI: 0.228–0.517, P < .001) and gastric cancer (HR = 0.341, 95% CI: 0.160–0.725, P = .005) patients with high miR-125a-5p expression. Besides, high miR-125a-5p expression was correlated with early stage (OR = 0.413, 95% CI: 0.228–0.749, P = .004) and negative lymph node metastasis (OR = 0.262, 95% CI: 0.073–0.941, P = .04) in gastric cancer, and was linked with better tumor differentiation in pan-cancer (OR = 1.623, 95% CI: 1.064–2.476, P = .025) and lung cancer (OR = 2.371, 95% CI: 1.358–4.141, P = .002). In conclusion, miR-125a-5p is a tumor suppressor with prognostic and clinicopathologic values for human cancer, and miR-125a-5p overexpression predicted favorable prognosis, early stage, negative lymph node metastasis, and better tumor differentiation. More research should be conducted to test these results.
Objective: To compare the changes of CT values of distal femoral artery and radial artery obstructive lesions and whether CTA showed the diagnosis of complete occlusion of lower extremity arteries by CT angiography and DSA. Materials and Methods: A total of 50 consecutive patients with femoral artery and radial artery occlusion were enrolled and retrospectively studied, aged 32–83 years, mean 68.5 ± 8.7 years old; 35 males and 15 females, reverse descending The sign was defined as the contrast fill gradient in the distal lumen of the vascular occlusion site, which was characterized by a progressive increase in the CT value of the distal lumen of the obstructed lesion from proximal to distal. DSA was used as the criterion to statistically analyze the incidence of CT angiographic inverse descending signs and collateral circulation in chronic complete obstructive lesions and partial obstructive lesions of the femoral artery and radial artery, and statistical analysis was performed. Results: The rates of reversed CT values in the chronic total occlusion group and the partial occlusion group were 76.9% (20/26) and 20.8% (5/24), respectively. The signs of reverse degeneration were significantly more common in the chronic complete occlusion group (X2 = 13.1). P < 0.05). The incidence of peripheral collateral circulation in the chronic occlusion group and partial obstruction group was 80.8% (21/26) and 29.2% (7/24), respectively. The incidence of collateral circulation in the chronic complete occlusion group was significantly higher than that in the partial occlusion group. Blocking group (X2 = 13.5, P < 0.05). The sensitivity of CT and angiographic collateral signs for the diagnosis of chronic complete occlusion of the femoral artery and radial artery was 92.3%, and the specificity was 70.8%. Conclusions: The inverse degeneration of CT values and the signs of CTA collateral circulation have a high specificity for the diagnosis of chronic complete occlusion of the femoral artery and radial artery, and help to identify partial occlusion of the femoral artery and radial artery and chronic complete occlusion.
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