Neurodegenerative disorders are one of the leading causes of death among the elderly. Therapeutic approaches with a single target have proven unsuccessful in treating these diseases. Structural combination of multi-functional compounds may lead to a molecule with multiple properties. In this study, we designed and synthesized T-006, a novel analog derived from two multi-functional neuroprotective chemicals, tetramethylpyrazine and J147. The methoxyphenyl group of J147 was replaced by tetramethylpyrazine. Bioactivity evaluation showed that T-006 at very low concentrations had multi-functional neuroprotective effects including rescuing iodoacetic acid-induced neuronal loss, preventing oxidative stress-induced neurotoxicity and reducing glutamate-induced excitotoxicity in vitro. Most importantly, T-006 significantly ameliorated memory impairments in APP/PS1 transgenic mice. These multiple functions of a single molecule suggest that T-006 is a promising novel neuroprotective agent for treating various neurodegenerative disorders, including and in particular Alzheimer's disease.
To expand the extent of conjugation with biologically active molecules (biopolymers, peptides, drugs, etc.) and biomaterial substrates, we synthesized a serial of poly (ethy1ene glycol) (PEG) derivatives (PEG-2000-NH2, MPEG-1200-NH2, and APEG-1200-NH2) in three efficient steps. The end groups were characterized by 1H NMR spectroscopy.
A method for the simultaneous determination of organochlorine pesticide and pyrethroids in tea was established by gas chromatography equipped with electronic capture detector (GC-ECD).The organochlorine and pyrethroids in tea were extracted by acetonitrile, then filtered and concentrated organic phase, and separated and purified through a florisil column, then concentrated again and diluted with hexane to scale. The organochlorine pesticide and pyrethroids were analyzed by GC-ECD and qualified with external standard method. Experiments show that seven kinds of agricultural chemicals’ peak time range from 16.362 to 32.010 min, correlation coefficient in the range of 0.9992-0.9999, with excellent linearity. The lowest examination limits range from 0.018 mg/kg to 0.099 mg/kg and the recoveries between74.5% and 116% with relative standard deviations(RSD) of 1.4%-8.7%. The results showed that proposed method could used to determine these two kinds of pesticides in tea.
The present work describes a solution-liquid-solid (SLS) synthesis route for the preparation of CdSe nanocrystal quantum dots using the low-melting-point Bi nanoparticles as catalysts. UV-vis absorption spectra were used to determine the growth of CdSe cluster. The shape and size distribution of the CdSe QDs were determined by analysis of Transmission electron microcopy (TEM) images. A peak wavelength of 399nm in the absorption spectra on day 5 indicated that the CdSe cluster formed. TEM micrographs showed that CdSe QDs had a relatively narrow distribution of QD size, and the diameter of CdSe QDs was about 4 nm. Our preliminary results illustrated that smaller size of CdSe QDs could be prepared by SLS method and it was small enough for bioimaging applications.
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