Chikusetsusaponin V (CsV), a saponin from Panax japonicus, has been reported to inhibit inflammatory responses in lipopolysaccharide (LPS)-induced macrophage cells. However, whether CsV could alleviate LPS-induced liver injury in vivo and the potential mechanisms involved remain unclear. In the present study, we investigated the anti-inflammatory effects of CsV on LPS-induced acute liver injury in mice and further explored the potential mechanisms involved. Our results showed that CsV significantly attenuated elevation of alanine transaminase (ALT) and aspartate aminotransferase (AST) levels and improved liver histopathological changes in LPS-induced mice. In addition, CsV decreased serum tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) levels and inhibited mRNA expressions of inducible nitric oxide synthase (iNOS), TNF-α and IL-1β in LPS challenged mice. Furthermore, CsV inhibited nuclear factor kappa B (NF-κB) activation by downregulating phosphorylated NF-κB, IκB-α, ERK, c-Jun N-terminal kinase (JNK) and p38 levels in the liver tissue, which ultimately decreased nucleus NF-κB protein level. In conclusion, our data suggested that CsV could be a promising drug for preventing LPS challenged liver injury since it attenuated LPS-induced inflammatory responses, partly via inhibiting NF-κB and MAPK signaling pathways.
Pneumatic splice makes use of high-speed compressed air as the driving force to complete the yarn splicing, noticing that the change of the vent pressure has a significant effect on yarn splicing. This paper studies the impact of vent pressure on the quality of yarn splicing when twisting and untwisting. Modeling, analysis and simulation of the air splice is done with the integration of Pro/E and ANSYS software, to study the flow filed and obtain the influence on the speed and pressure of the inside the splicing chamber when changing the speed and pressure while keeping the diameter of splicing chamber diameter, the vent hole diameter and the relative angle are unchanged. The results of the analysis of the air splice will lay a solid foundation for the further optimized structure design.
The yarn tension is an important parameter to determine the product quality and production efficiency in winding process. Appropriate winding tension makes the winding bobbin form, which is a compact structure without damaging the physical and mechanical properties, is conductive to smoothly unwinding after the back working procedure.This paper makes analysis of The principle, composition and factors affecting the yarn tension of a winding machine, so as to control the yarn tension constancy of the yarn theoretical basis.
The loader's steer-by-wire system combines the automatic control system and hydraulic system. The system cancels the mechanical or hydraulic connection between the steering wheel and the front wheels, which existed in the original steering system, optimizing the adaptation of the loaders steering systems road feeling to its working conditions, convenient for the integration with other systems, and harmonization of control. This paper puts forward a new measurement of a steer-by-wire system steering angel. It aims at more accurate corner detection, will design to optimize loader's steer-by-wire hydraulic system signal detection, and better meet the actual needs.
Based on the study on metal cutting theories and rigid-plastic finite element method, taking Sweden SECO lathe tool MDT as the researching object, the cutting force in cutting process is analyzed after a cutting process simulation model is constructed using finite element method. Different simulation parameters and cutting parameters are used to carry out analyses time after time. The dynamic changing curves of the cutting force in cutting process are obtained. Through the comparison of the cutting force in different cutting conditions, the influence of cutting parameters on the cutting force is summarized. The research can provide useful data for improvement of metal cutting technology and tool cutting performance.
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