These days, the classification between normal and cancerous tissues and between different types of cancers represents a very important issue. Selecting the little informative number of genes is considered the main challenge in the cancer diagnosis issue. Therefore, Gene selection is usually the preliminary step for solving the cancer classification problems. Bio-inspired metaheuristic optimization algorithms, when used to solve gene selection and classification problems, they demonstrate their effectiveness. Barnacles Mating Optimizer (BMO) algorithm, which imitates the behavior of mating barnacles in nature for solving optimization problems, is considered one of these algorithms. In this paper, Barnacles Mating Optimizer (BMO) algorithm augmented with Support Vector Machines (SVM) called BMO-SVM is proposed for a microarray gene expression profiling in order to select the most predictive and informative genes for cancer classification. Conducting a comparative experimental study among a set of the most common bio-inspired optimization techniques to specify the most effective. A binary microarray dataset (i.e., leukemia1) and a multi-class microarray dataset (i.e., SRBCT, lymphoma, and leukemia2) are used for testing the performance of the proposed model. The experimental results revealed the superiority of the proposed BMO-SVM approach against several well-known meta-heuristic optimization algorithms, such as the Tunicate Swarm Algorithm (TSA), Genetic Algorithm (GA), Particle Swarm Optimization (PSO), and Artificial Bee Colony (ABC). It is worth mentioning that our proposed algorithm achieves a high informational superiority percentage compared to other algorithms.
It is crucial to accurately categorize cancers using microarray data. Researchers have employed a variety of computational intelligence approaches to analyze gene expression data. It is believed that the most difficult part of the problem of cancer diagnosis is determining which genes are informative. Therefore, selecting genes to study as a starting point for cancer classification is common practice. We offer a novel approach that combines the Runge Kutta optimizer (RUN) with a support vector machine (SVM) as the classifier to select the significant genes in the detection of cancer tissues. As a means of dealing with the high dimensionality that characterizes microarray datasets, the preprocessing stage of the ReliefF method is implemented. The proposed RUN–SVM approach is tested on binary-class microarray datasets (Breast2 and Prostate) and multi-class microarray datasets in order to assess its efficacy (i.e., Brain Tumor1, Brain Tumor2, Breast3, and Lung Cancer). Based on the experimental results obtained from analyzing six different cancer gene expression datasets, the proposed RUN–SVM approach was found to statistically beat the other competing algorithms due to its innovative search technique.
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