Cervical extradural tumor is one of the rare tumors and can cause progressive neurological problems. Neurological deficit in productive age greatly affects the patient's quality of life. Surgical management is carried out with the aim of reducing pain, improving neurological conditions, and improving the patient's quality of life. A 25-year-old woman had progressive tetraparesis since 2 months prior to admission, MRI showed an extradural mass compressing the spinal cord at the level of the C1-3. The surgery was performed under the principles of neuroanaesthesia. On postoperative assessment, motor strength function has improved significantly. A extradural tumor patient was excision by operation with 850 mm bleeds and good recovery with improvement motoric function in all extremities Good perioperative management is needed in patients with spinal tumors, especially patient with tumors on the cervical levels. The anticipation of iatrogenic spinal cord trauma and bleeding has to be maintained during the surgery. Neurological evaluation and rehabilitation of patients is carried out by involving a multidisciplinary team. Spinal cord tumour with excise in neurosurgery at the right time and good perioperative neuroanesthesia will good outcome and improve neurologicals deficit.
This study aimed to determine the effect of neem leaf extract on the seminiferous tubules of white rats. This study used 15 adult white rats which divided into 5 treatment groups. The control group was only given water and each treatment group was given neem leaf extract with the dose of 50 (P1), 100 (P2), 150 (P3), and 200 (P4) mg/kg BW orally for 30 days. The rats were then euthanized with chloroform and the testicular organs were collected for histopathological preparations using Haematoxylin and Eosin staining method. The data were analyzed descriptively. The results showed that there were no histological changes of seminiferous tubules in control group as well as in P1 group. Spermatogenic cells, Sertoli cells, lamina basalis, and interstitial connective tissue started to lyse and thin out were observed in P2. In P3 group, the Sertoli cells, basal laminae, and interstitial connective tissue showed partial lysis. Meanwhile, in P4 showed lysis of the interstitial connective tissue in each tubule. This study showed that seminiferous tubule damage is dose-dependent with the administration of neem leaf extract. In conclusion, neem leaf extract could affect the spermatogenesis process at the dose of 150 mg/kg BW and 200 mg/kg BW.
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