Objectives: In this study we investigate the effectiveness of lycopene in themanagement of oral submucous fibrosis (OSF) when intralesional steroids also given incombination. Study Design: Cross sectional study. Setting: Dental Section Allied Hospital,Faisalabad. Period: Eight months from September 2016 to April 2017. Methodology: This crosssectional study was initiated after approval from hospital ethical board. Collected Informationwas entered in SPSS computer software version 23 and analyzed for possible results. Meanand SD was calculated and presented for quantitative data like age, VAS score and mouthopening. Frequency (percentages) were calculated and presented for qualitative data such asgender. Post stratification statistical chi square test was used to see effect modification. P value≤ 0.05 was considered as significant. Results: Overall, there were 100% (n=354) patients.Total patients who were selected for the study had the habit of chewing areca nut either innatural form or in the form of Pan Masala, gutkha or mawa. Gutkha is the most common formof areca nut used, i.e. 65.8% (n=233) patients were using it. In our study average increase inmouth opening from baseline (before treatment) was 5.12±1.03 mm in group A. 4.20±1.26mm in group B and 3.40±0.19 mm in group C at six week. Conclusion: When Lycopene usedcombined with intralesional steroids and Hyaluronidase its effectiveness is better in improvingthe mouth opening its symptoms in patients with Oral Submucous Fibrosis (OSF). It was alsofound that there was no side effects.

In this study we investigate the effectiveness of lycopene in the management of oral submucous fibrosis (OSF) when intralesional steroids also given in combination. Study Design: Cross sectional study.