We demonstrate a novel fabrication technology of the microneedle array applied to painless drug delivery and minimal invasive blood extraction. The fabrication technology consists of a vertical deep X-ray exposure and a successive inclined deep X-ray exposure with a deep X-ray mask whose pattern has a hollow triangular array. The vertical exposure makes triangular column array with a needle conduit. With the successive inclined exposure, the column array shapes into the microneedle array without deep X-ray mask alignment. Changing the inclined angle and the gap between the mask and PMMA (PolyMethylMetaAcrylic) substrate, different types of microneedle array are fabricated in 750-1000 lm shafts length, 15 o -20 o tapered tips angle, and 190-300 lm bases area. The masks are designed to 400-600 lm triangles length, 70-100 lm conduits diameter, 25-60EA/5 mm 2 arrays density, and various tip shapes such as triangular, rounded, or arrow-like features. In the medical application, the fabricated PMMA microneedle array fulfills the structural requirements such as three-dimensional sharp tapered tip, HAR (High-AspectRatio) shafts, small invasive surface area, and out-of-plane structure. In the skin test, the microneedle array penetrates back of the hand skin with minimum pain and without tip break and blood is drawn after puncturing the skin. Hot embossing process and mold fabrication process are also investigated with silicon and PDMS mold. The processed tetrahedral PMMA structures are fabricated into the microneedle array by the additional deep X-ray exposure. With these processes, the microneedle array can be utilized as the mold base for electroplating process.

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Abstract-In this paper, accelerated techniques for three dimensional ray tracing using the concept of ray frustums are presented for the fast characterization of wireless communications, where various radio propagation paths such as wall-transmitted wave and scattered wave from buildings and ground are generated. To accommodate such scatterers, objects are modeled by triangulated meshes, and potential ray paths are searched and stored in the form of ray frustums. The presented acceleration techniques using the frustums include sorting of triangulated surfaces, hashing functions and space partitioning. The validity of the method is verified by comparison with measurement data.

Abstract-In this paper, an analysis method for optical wave propagation based on photon model is presented for the characterization of optical wireless communication environment. In contrast to radio waves, optical waves have very short wavelengths, so that material properties become important and often cause diffuse reflections. Channel models including diffuse reflections and absorption effects due to material surface textures make conventional electromagnetic wave analysis methods based on ray tracing consume enormous time. To overcome these problems, an analysis method using photon model is presented that approximates light intensity by density of photons. The photon model also ensures that simulation time is within a predictable limit and the accuracy is proportional to the number of total photons used in the simulation.

Mature zygotic embryos dissected from ginseng (Panax ginseng C.A. Meyer) seeds were cultured on Murashige and Skoog (MS) medium containing various concentrations of 2,4-D and kinetin. Somatic embryos were induced directly from cotyledonary tissue and from intervening callus. The frequency of somatic embryo induction was up to 55% of zygotic embryo explants. Upon transfer onto half-strength MS medium supplemented with 1 mg BA/liter and 1 mg GA3/liter, most somatic embryos developed into plantlets. More than 50% of the plantlets flowered after 4 weeks of culture, and some developed immature fruits in vitro. These results indicate that adulthood of ginseng root explants is not a prerequisite for flowering of plantlets regenerated through somatic embryogenesis. Chemical names used: (2,4 -dichlorophenoxy) acetic acid (2,4-D); N-(2-furanylmethyl) -1H-purin-6-amine(kinetin); N-(phenylmethyl) -1H-purin-6-amine (BA); gibberellic acid (GA3).

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The aggregation and dispersion of nanoparticles are critical problems in selective laser sintering. In this study, negative pressure aging was applied to resolve the aggregation of nanoparticles and a metal oxide reduction method used to make a well-dispersed nanoparticles in solvent. As a result, metal oxide nanoparticles were synthesized according to a grade of the aggregation and aging conditions found to provide well-dispersed nanoparticles in solvent with less re-dissolution of the nanoparticles. Furthermore, a coating quality and characteristics of laser induced sintering were analyzed according to the grade of the aggregation. The coating quality was affected by the aggregation and the statistical dispersion of nanoparticles. The coating deposited by particles with a wide statistical dispersion has a better quality when compared with the coating prepared from particles with a narrow dispersion. The quality of laser sintered electrode depends on the aggregation but the dependency of the aggregation diminishes as the irradiation of the laser power is decreased.