There are few estimates of influenza burden in the WHO Region for the Eastern Mediterranean. In this study we estimated the burden of severe acute respiratory infection (SARI) and influenza-associated SARI (F-SARI) in selected provinces of Islamic Republic of Iran, the trends of SARI and confirmed cases of influenza (F-SARI) over 12 months (seasonality), and the age groups most at risk. Using the electronic Iranian influenza surveillance system and data of cases in sentinel hospitals of 3 selected provinces, we estimated the monthly trend (seasonality) of incidence for SARI and F-SARI, overall incidence of SARI and F-SARI and their disaggregation by age with the aid using the Monte Carlo technique. The age groups most at-risk were children aged under 2 years and adults older than 50 years.
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related complication leading to readmission or reintervention within 30 days), 30-day mortality, estimated blood loss (EBL), use of blood transfusions, total operative and fluoroscopy time, and hospital and intensive care unit (ICU) stay. Patients with TPFA were compared to patients who needed SFA on one or both sides. Results: A total of 231 patients (mean age 75 years; males n¼165, 71%) were included in the study. TPFA was performed in 168 (73%) while SFA was performed in 68 (27%, 45 iliofemoral conduits). Technical success rate of TPFA was 93%, with 2 unilateral conversions for limb ischemia and 9 unilateral conversions for access bleeding. Nearly all conversions were on the side of the main body insertion (10/11). There were 9 access site complications at 30 days after TPFA (4 ischemia, 5 bleeding) and 56% were on the main body delivery side (5/9). Analysis of time trend of accessi site complications for TPFA did not reveal any sginificant difference (p¼.51). Despite more complex access, there were no differences in fluoroscopy time, 30-day mortality, as well as hospital sand ICU stay between TPFA and SFA groups. As expected,TPFA was associated with a shorter total operative time (229AE71 vs. 304AE85 minutes, p< .001), lower estimated blood loss (369AE453 vs. 731AE639 ml, p< .001), less use of blood transfusions (21% vs 37%, p¼.013), and reduced rates of 30-day access-related complications (6% vs 21%, p< .001) compared to SFA (Table). For TPFA, large sheath access time and total vessel access time on the main body side were limited to 120 (AE57) minutes and 145 (AE60) minutes respectively. Conclusion: Use TPFA for elective F-BEVAR can be safely and effectively performed with a high technical success rate in eligable patients with minimal large sheath time. When needed, SFA carries higher risk of peri-operative complications. Percutaneous access offers potential benefits and should be the preferred option for femoral access during elective F-BEVAR in patients with suitable arterial anatomy.
We evaluated the safety and efficacy of a resveratrol-paclitaxel-coated peripheral balloon catheter in an all-comer patient cohort undergoing endovascular treatment of above-the-knee and below-the-knee peripheral artery disease. CONSEQUENT ALL COMERS (Clinical Post-Market Clinical Follow-up [PMCF] on Peripheral Arteries treated with SeQuent Please OTW [Over-the Wire]) is a prospective, single-arm, multicenter observational study (ClinicalTrials Identifier: NCT02460042). The primary end point was the 12-month target lesion revascularization (TLR) rate. Secondary end points included vessel patency, target vessel revascularization, and all-cause mortality. A total of 879 lesions in 784 consecutive patients (71.3 ± 10.4 years old, 57.7% male) were analyzed; 53.3% had claudication, whereas the remaining 46.7% exhibited critical limb ischemia (CLI). Substantial comorbidities were present, including diabetes mellitus (41.2%), smoking (66.1%), and coronary artery disease (33.9%). Lesion length (879 lesions) was 12.0 ± 9.3 cm and 31.8% were Transatlantic Inter-Society Consensus II C/D lesions. The overall technical success rate of the 1269 drug-coated balloon (DCB)’s used was 99.6% (1.60 ± 0.79 DCB’s/patient). At 12 months, the TLR rates were 6.3% in patients with CLI and 9.6% in claudicants, with a primary patency rate of 89.9% and 87.1%, respectively. All-cause mortality was 4.3% (28/658). Predictors for TLR were in-stent restenosis at baseline, vessel diameters ≤ 4.5 mm, lesion length, and post-DCB bailout stenting.
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