Among a number of different heterogeneous and homogeneous catalysts, silica boron-sulfuric acid nanoparticles (SBSANs) with both protic and Lewis acidic sites were shown to be the most active and recyclable catalyst in the Ritter reaction. Various amide derivatives were synthesized from alcohols and nitriles via a one-step and easy process in the presence of a catalytic amount of SBSAN at room temperature in solvent free conditions with excellent isolated yields. The silica boron-acid nanoparticles (SBANs) were regularly synthesized during the modification of the silica support by boric acid [B(OH) 3 ] during the chemical vapor deposition (CVD) process and subsequently, this material was reacted with chlorosulfonic acid (ClSO 3 H) to obtain the SBSAN catalyst. The new catalyst was characterized using some different microscopic and spectroscopic techniques such as patterned X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), FT-Raman spectrometry and FT-IR spectroscopy. Thermal behavior of the SBSAN catalyst was also investigated by a thermogravimetric (TG) analyzer.
A simple, clean and highly efficient method for the preparation of polyhydroxyl aromatic compounds is described from the reaction of 2,6-bis(methylol)phenols and different substituted phenols in the presence of silica sulfuric acid (SSA) as a heterogeneous catalyst. SSA afforded the clean synthesis of target compounds in much higher yields than traditional catalysts. The established method is also suitable for the synthesis of phloroglucinol derivatives (Phloroglucides) and other polyhydric phenols. Besides the easy work-up of the reaction mixture, the comfortable purification of the products is another advantage of this method.
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