<b><i>Introduction:</i></b> While vaccines may be a key measure in overcoming the pandemic, their hesitancy among the population may impede the ongoing efforts of governments and health authorities in a country. Universities are considered the hubs of the transition of individuals to young adults, understanding the hesitancy of this population stratum and addressing apprehensions that may exist is of utmost importance. This study aims to explore the attitude and hesitancy of students in UAE universities toward the COVID-19 vaccines along with comparing two particular demographics to see if there exists a difference in outcomes-medical and nonmedical students. <b><i>Methods:</i></b> A web-based self-administered questionnaire was sent following Ethics Committee approval, to students at various universities in the UAE containing questions regarding general demographic data, COVID-19 related anamnestic characteristics as well as questions on motivational factors and refusal factors regarding the vaccine. Using Statistical Package for the Social Sciences version 28, descriptive analyses were performed for the demographic variables and inferential statistics were carried out using Pearson’s Chi-squared (χ²) test. <b><i>Results:</i></b> A total of 385 participants consented to the survey, with a majority of female respondents (76.6%). In our demographics which included respondents of an average age of 21 years, 91.4% were expatriates, and 48.1% were based in Dubai. Approximately 67% of those surveyed had been vaccinated, with Sinopharm being the most commonly taken vaccine (70.4%). “Concerns over side effects” seems to be the most common reason for vaccine refusal (58.7%) among all demographics whether vaccinated or not. Our sample included a majority of students with a medical and health sciences background (58.7%), who disagreed more often with the belief that they were completely protected by receiving the COVID-19 vaccine as compared to the nonmedical students. <b><i>Conclusion:</i></b> COVID-19 vaccination rates among university students in UAE are lower than the national average, demonstrating the importance of integrating a specific awareness program for this group. Preparing medical students for the future is a beneficial long-term strategy, and hence, further research regarding vaccine hesitancy must be done focusing primarily on them to ensure their future patients receive the best vaccine-related recommendations.