Most epidemiological surveys have focused on a single or just one group of ABD. In our series, pemphigus foliaceus was relatively more prevalent than in occidental data. The frequencies of subepidermal immunobullous dermatoses in our study were in agreement with those in the literature.

To study the mutation spectrum and phenotype-genotype correlation of Darier disease (DD) in Tunisian patients.

immunologic responses and our patient acquired allergy to Entecavir during this treatment. Possible adverse skin effects due to Entecavir were present (personal communication, Bristol-Myers K.K.) in Japan. To our knowledge, there were no reports about cutaneous immediate allergy induced by Entecavir, which was confirmed by skin testing. If it is possible to get the ingredients of Entecavir, we might find what causes his allergy.with a chronic conjunctival and corneal inflammation, and with subsequent scarring.Application of tacrolimus ointment on eyelids is a promising treatment of AKC in patients with both blepharitis and keratoconjunctivitis. 2-7 Tacrolimus ointment may have a sparing steroid and cyclosporin effect in keratoconjunctivitis.Tacrolimus ointment has a good tolerability and safety profile, but trials with expanded periods of treatment and careful follow-up are necessary to evaluate long-term safety profile. 9,10

Transgressive palmoplantar keratoderma (PPK) is the phenotypic hallmark of Mal de Meleda (MDM, MIM 24300). It is characterized by erythema and hyperkeratosis that extend to the dorsal face of the hands and feet. The disease is distributed worldwide and includes the Mediterranean population. The gene responsible for MDM, ARS (component B) mapped on chromosome 8qter, encodes for the SLURP-1 protein (Ly-6/uPAR related protein-1). A variety of mutations within the ARS gene have been shown to underlie MDM in different populations. Genetic heterogeneity of MDM is suspected. We have recently shown that three different homozygous mutations (82delT, C77R, C99Y) were responsible for MDM in 17 patients from Northern Tunisia belonging to eight unrelated consanguineous families. We report here a Tunisian family with three siblings presenting with recessive transgressive PPK closely resembling the MDM phenotype that excludes linkage to the ARS gene.

DD skin displayed a constant immunohistochemical involucrin pattern characterized by both premature expression and a particular cytoplasmic/cell membrane localization distribution.