Breast cancer is the most common malignancy observed in females. Histologically, breast cancer is a heterogeneous disease with different subtypes and pathology, treatment options and prognosis. 1 Bryan et al 2 for the first time in 2006 explicitly presented the definition of triple-negative breast cancers (TNBCs) based on the expression of oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). Other studies using gene expression profiling were able to classify breast cancer into five subtypes. 3,4 To date, TNBC is used frequently as a standard procedure to classify breast cancer patients for clinical care. TNBC is similar to the basal-like subtype, which is characterized by negative ER, PR and HER2 expression, and is associated with aggressive histology, poor prognosis and unresponsiveness to the endocrine therapies. 5,6 Moreover, TNBC has been used as a surrogate marker for the basal-like breast cancer, and approximately 80-90% of TNBCs are basallike breast cancers.7 Younger females have a higher rate of basal or breast cancer susceptibility gene mutation-related TNBC, whereas older females have a higher proportion of apocrine, normal-like and rare subtypes of TNBC, including neuroendocrine TNBC.8 Because only fewer specific targeting therapies and molecular therapies (such as endocrine or target therapy) are available than for other subtypes of breast cancer, the standard treatment for TNBC includes surgery combined with adjuvant chemotherapy and radiotherapy, but clinical outcome is poor. 7,9 Thus, early detection of this subtype of breast cancer is vital to improve the survival of patients.Although TNBC has been studied extensively in clinical and pathological literature, there are few reports on the radiological characteristics of this subtype of breast cancer. To date, mammography is known to be a precise diagnostic technique with high sensitivity and specificity in the evaluation of breast lesions, and the current reference standard in breast cancer screening is mammography with the sensitivity to detect early-stage breast cancer. Therefore, this study evaluated the mammographic and clinicopathological