Secretion of coproporphyrin III by suspensions ofArthrobacter phorogonimos and A. globtjiwmis facilitated analysis of the paths of synthesis of &aminolevulinic acid, the precursor of tetrapyrroles. Sensitivity of coproporphyrin accumulation to gabaculine and incorporation of 14C from [I-"C]glutamate indicated that suspensions of A. photogonimos synthesized S-aminolevulinic acid from glutamate by the widespread C5 pathway. In contrast, A. glob@-mis cells switdhed from predominantly the C5 pathway for d-aminolevulinic acid synthesis in early exponential phase cultures to Gamitiolevulinic acid synthase in stationary phase cultures.
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