The present study is related to develop novel colon specific drug delivery systems using chitosan and pectin as a microbially degradable polymeric carrier. Alkyl-pectin with various degrees of substitution were prepared by heterogeneous alkylation of pectin with alkyl bromide. The results showed that the alkyl-pectin with insolubility can be obtained based on the optimal reaction condition. The ratio of pectin to 1-bromoctane mole number was 1:9, reaction time is 8 h with temperature of 80 ºC and the weight ratio of tetrabutyl ammonium bromide to pectin is 0.5 %. The alkyl-pectin structure were characterized by FT-IR Elemental analyses, differential scanning calorimetry analysis and 1 H NMR analysis. The findings of the present study conclusively state that alkyl-pectin are promising for colon targeting of drugs.
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