This double-blind, randomised, parallel-group trial compared the analgesic efficacy of single 50 mg doses of diclofenac potassium sachets and tablets with placebo in 184 patients with moderate/severe pain after third molar extraction. The primary efficacy variable was the average pain reduction from baseline during the first 2-h postdose, using a visual analogue scale (VAS). During the first 2-h postdose, sachets and tablets significantly reduced pain (p < 0.05) vs. placebo with an incremental benefit seen for sachets over tablets (p < 0.05). Onset of analgesic effect (VAS) was at 30 min for sachets and 45 min for tablets. Pain reduction vs. placebo (VAS) was maintained for 8 h for sachets and tablets (p < 0.05). VAS-findings were confirmed by pain relief and intensity verbal scale assessments. Fewer patients re-medicated vs. placebo. No safety issues were identified. This study demonstrates that both diclofenac potassium sachets and tablets offer patients suffering from acute pain conditions an effective treatment with incremental analgesic benefits seen for sachets.
Die Hexacyanochromate(III) von Li+, Na+, K+, Rb+, Cs+, NH4+, [(C4H9)4N]+, [(C6H5)4P]+, [(C6H5)4As]+ und Tl+ wurden präpariert und röntgenographisch vermessen. In den Remissionsspektren wurde eine bisher unbekannte Elektronenüberführungsbande bei 45 kK gefunden, die in einigen Fällen eine Schwingungsstruktur besitzt. Die Phosphoreszenzintensität hängt stark von der Art des Kations ab. Die Bandenlagen in Emission und Remission unterscheiden sich bei den einzelnen Komplexsalzen nur geringfügig.
Die Gesamtquantenausbeute der selbst‐sensibilisierten Photooxidation des Rubrens wurde in Benzol, Toluol, Chloroform, 1,2,4‐Trichlor‐benzol, Tetrachlorkohlenst off und Schwefelkohlenstoff in Abhängigkeit von der Sauerstoffkonzentration und der Rubrenkonzentration bei 25 ± 2°C gemessen. Weiterhin wurden die relativen Fluoreszenzquantenausbeuten, die Fluoreszenzabklingdauern und die Konstanten für die Sauerstofflöschung der Fluoreszenz ermittelt. Die Analyse der kinetischen Daten steht mit der Annahme im Einklang, daß Singulettsauerstoff sowohl durch Rubrenmoleküle im ersten angeregten Singulettzustand als auch durch Rubrenmoleküle im niedrigsten Triplettzustand erzeugt wird. Es wird gezeigt, daß die Abhängigkeit der Photooxidation des Rubrens vom Lösungsmittel vornehmlich durch die unterschiedlichen Lebensdauern des Singulettsauerstoffs in verschiedener Umgebung bedingt wird.
Cleidocranial dysplasia (CCD) and the Rubinstein-Taybi syndrome (RTS) are two rare congenital syndromes that have many clinical signs in common. We present an 18-year-old-patient with untypical CCD expression who was misdiagnosed with RTS at the age of 2 years. An extensive craniofacial examination was carried out with respect to morphological and dental aspects. The molecular-genetic analysis of two underlying genes (CBFA1 and CBP) for CCD and RTS was performed using SSCP, direct sequencing and FISH. While the clinical examination showed uncharacteristic CCD symptoms with some findings common for RTS, the molecular-genetic analysis revealed a missense mutation in the CBFA1 gene, which is considered to be the etiological factor for CCD. Our findings with this patient presented clear evidence for the wide morphologic variety that can be related to a certain gene such as CBFA1. The diagnosis of rare diseases is currently based on the clinical phenomenology of small groups or single cases. The use of molecular-genetic biology extends the horizon of diagnostic and scientific possibilities. In this patient, it allowed us to compare the clinically diagnosis to molecular-genetic data. We conclude that molecular-genetic analysis may be a helpful tool in the differential diagnosis of many congenital diseases such as CCD and RTS.
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