An on-line flow iniection -solid-phase extraction-capillary zone electrophoresis (FI-SPE-CZE) method has been developed for determination of cimetictine in human plasma. Sodium docte-@sulfate (SDS) was used as dynamic chemical modifier for elimination of capillary contamination by biological macromolecules. FI on-line preconcentration and cleaning of the analyte by means of a Cm microcolumn was performed automatically and CZE separation was performed consecutively without interruption of the applied voltage and belween-run-washing of the capillary. A detection limit of 8 l.tg L -1 (3 x ~) was achieved at a sample throughput of 12 h -1. The approach was successfully used for a pharmacokinetic study of cimetictine.
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