The metabolism of the systemic insecticide Temik has been investigated in the cotton plant and in the housefly using C14-labeled radiotracers and column and thin layer chromatography. Temik is readily and completely oxidized to its sulfoxide within 4 to 9 days in cotton leaves at moderate temperatures. The sulfoxide which is more active as a cholinesterase inhibitor is the active metabolite and its long term persistence and rela-
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