The relationship between hydrophobicity of triazoles and their adsorption and passivation ability in relation to copper is analyzed. Adsorption of triazoles on oxidized copper surface is polymolecular. Adsorption of the first monolayer is described by Frumkin equation with the free energy of adsorption in the range of 51-70 kJ/mol. Certain triazoles are able to effectively inhibit anodic dissolution of copper in neutral chloride solutions. The possible spatial arrangement of the triazoles on the surface of oxidized copper is revealed.
The effect of 6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline on markers of hepatocytes cytolysis (aspartate aminotransferase, alanine aminotransferase and gamma-glutamyl transpeptidase), parameters reflecting the state of oxidative status (intensity of biochemical luminescence and the content of diene conjugates), and the activity of oxidative metabolism enzymes (aconitate hydratase, glucose-6-phosphate dehydrogenase, NADP-isocitrate dehydrogenase) was studied in rats with CCl4-induced liver injury. The results obtained in the course of the work demonstrated the ability of the test compound to reduce the severity of oxidative stress and liver cells damage, as well as to change the activity of aconitate hydratase and NADP-generating enzymes in the direction of control values. 6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline was more effective in normalizing CCl4-induced changes of the analyzed parameters that Carsil used as a reference compound. The tendency to normalize the state of oxidative status and enzyme activity of oxidative metabolism can attributed to hepatoprotective and antioxidant properties of the tested compound.
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