Surface nanofeatures and bioactive ion chemical modification are centrally important in current titanium (Ti) oral implants for enhancing osseointegration. However, it is unclear whether the addition of bioactive ions definitively enhances the osteogenic capacity of a nanostructured Ti implant. We systematically investigated the osteogenesis process of human multipotent adipose stem cells triggered by bioactive ions in the nanostructured Ti implant surface. Here, we report that bioactive ion surface modification (calcium [Ca] or strontium [Sr]) and resultant ion release significantly increase osteogenic activity of the nanofeatured Ti surface. We for the first time demonstrate that ion modification actively induces focal adhesion development and expression of critical adhesion–related genes (vinculin, talin, and RHOA) of human multipotent adipose stem cells, resulting in enhanced osteogenic differentiation on the nanofeatured Ti surface. It is also suggested that fibronectin adsorption may have only a weak effect on early cellular events of mesenchymal stem cells (MSCs) at least in the case of the nanostructured Ti implant surface incorporating Sr. Moreover, results indicate that Sr overrides the effect of Ca and other important surface factors (i.e., surface area and wettability) in the osteogenesis function of various MSCs (derived from human adipose, bone marrow, and murine bone marrow). In addition, surface engineering of nanostructured Ti implants using Sr ions is expected to exert additional beneficial effects on implant bone healing through the proper balancing of the allocation of MSCs between adipogenesis and osteogenesis. This work provides insight into the future surface design of Ti dental implants using surface bioactive ion chemistry and nanotopography.

Dipolarization of the magnetic field at the near‐Earth tail is usually associated with the local reduction of pV5/3 compared to that of the background, where p is the plasma pressure and V is the volume of the unit magnetic flux tube. This can be interpreted as a bubble, which can propagate earthward by the interchange process. How deep such a bubble can penetrate earthward, and what is the critical factor are critical questions that need to be answered. In this paper, we examine these issues by comparing near‐tail observations by inner probes of THEMIS with geosynchronous magnetic observations by GOES. We identified a number of bubble events associated with near‐tail dipolarization, which we call “tail bubble,” and checked geosynchronous disturbances. We find a statistical trend that geosynchronous disturbance is more likely to occur when associated with (or when hit by) an earthward moving tail bubble with a more‐depleted pV5/3. We estimated the background pV5/3 profile statistically and used it to determine expected equilibrium (or stop) positions for earthward moving bubbles where the bubble's pV5/3 is equal to that of the background. Statistically, we find that the equilibrium position is more inward for tail bubbles with a lower pV5/3, for which the probability of causing geosynchronous disturbance is higher. For example, the probability of a tail bubble being associated with geosynchronous disturbance is 75% if the bubble's equilibrium position is <8 RE. However, for all the events studied here, the bubble equilibrium positions are still outside the geosynchronous altitude. Although this result may be subject to change due to the uncertainty in estimating pV5/3 and the limited number of the events identified near geosynchronous altitude, we suggest that an overshooting of the penetrating bubbles beyond equilibrium positions is a possible explanation.

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The binding properties of dibenzo-18-crown-6 ether (BTB, 1) and napthobenzo-18-crown-6 ether (NTB, 2), containing two thiazole units toward mono, and divalent cations, are outlined. The ion-selective properties of 1 and 2 were studied by measuring their fluorescent emission responses to alkali, alkaline earth, and transition metal ions. BTB (1) showed the highest binding constant toward Ag 1 over Pb 21 , Hg 21 , and Cu 21 . NTB (2) revealed a high selectivity toward Ag 1 over Pb 21 , Hg 21 , and Cu 21 .