Contents of aflatoxin B 1 (AFB 1 ) and ochratoxin A (OA) in the samples of wheat and barley were detected by RIA method. Average contents of AFB 1 in the samples of wheat and barley were 2.4 µg/kg and 2.2 µg/kg, respectively. Average contents of OA in the samples of wheat and barley were 3.1 µg/kg and 2.4 µg/kg, respectively. The contents of mycotoxins corresponded to the allowed limits in food. During the studies of mutagenic activity of mycotoxins and their combinations by means of Ames test it was found that OA could increase the mutagenicity of AFB 1 in the case of their simultaneous occurrence in the same substrate. For free full paper in pdf format see
Z. Sova, Hana Pohunkova, Hana Reisnerova, AUbeta SIamova, K. Haisl: Hematological and Histological Response to the Diet Containing Aflatoxin Bl and Zeolite in Broilers of Domestic Fowl. Acta vet. Brno, 60,1991: 31-40: The experiment was performed on twenty nine healthy broilers from the school farm. The birds were divided into four groups: control group I, group II fed with diet to which 5 % of zeolite . kg-I was added, group III fed with diet containing. 5 % of zeolite and 2 . 5 mg of aflatoxin Bl • kg I, and group IV fed with diet with only 2.5 mg of aflatoxin B1 . kg-I. Three or four broilers from each group were killed after five and twelve days of the experiment. Broilers in the group IV showed both serious heterophilia and lymphopenia. In the group III this shift was not so evident. In both groups III and I V features of acute alteration of liver parenchyma charracterized by the activation of Kupffer's cells and by dilatation of bile canaliculi and cholestasis were found. Similar focal changes were revealed also in liver tissue or broilers in the group II after twelve days of experiment. Results obtained suggest not only that the addition of 5 % of zeolite. kg-l to the food does not protect liver tissue' against toxic effects of aflatoxin Bl but also that zeolite itself is not harmless for broilers.
Broilers, zeolite, aflatoxin Bu hematology, liver histology
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