The effect of separately selected chemical agents Dissolvan 4411, Alkan 415, ND-12 and Gossipol resin, as well as their new compositions in the ratio Dissolvan 4411+ Alkan 415 + ND-12 + Gossipol resin = 1:1:1:1 (conventional name А-1) and ND-12 + Gossipol resin = 3:1 (conventional name А-2) on the physical-chemical characteristics of oil samples taken from Azerbaijani fields Muradkhanly, Bulla-deniz, Balakhany-Sabunchu-Ramana, Neft Dashlary and Surakhany has been studied. The process was carried out in two hours in the laboratory conditions at 20 °С temperature. Dissolvan 4411, Alkan 415 and ND-12 demulsifiers were taken in 600 g/t, Gossipol resin – in 200 g/t, and А-1 and А-2 compositions – in 800 g/t ratio correspondingly. It was defined that two hours after adding Dissolvan 4411, Alkan 415, ND-12, А-1 and А-2 compositions at 20 °С temperature into the oil samples from Muradkhanly, Bulla-deniz, Balakhany-Sabunchu-Ramana, Neft Dashlary and Surakhany fields, the parameters of density, viscosity, water content, chloride salts and mechanical impurities sharply decrease. The composition of resin, asphaltene and paraffin compounds increases. The freezing temperature in the oil samples from Muradkhanly and Bulla-deniz fields do not change while in the samples from Balakhany, Neft Dashlary and Surakhany fields it dramatically reduces. The results of comparative analysis carried out at 20 °С temperature in the laboratory tests revealed that specifically А-1 and А-2 compositions mostly affect the improvement of physical-chemical characteristics of oil samples from Muradkhanly, Bulla-deniz, Balakhany-Sabunchu-Ramana, Neft Dashlary and Surakhany fields. It justifies that the employment of multi-functional compositions in the preparation to transportation of heavy oils is more efficient.