An association between certain persistent oral dyskinesias and medication with phenothiazines has been observed in middle-aged and elderly women for several years. In most of the published reports it is held that the phenothiazines are an important cause of the abnormal movements, since phenothiazines are known to exert a selective action on the basal ganglia. Other possible causes, however, are almost invariably present. These are brain damage from disease, leucotomy or electroconvulsive therapy (Hunter, Earl and Janz, 1964; Hunter, Earl and Thornicroft, 1964; Uhrbrand and Faurbye, 1960), and buccal factors such as ill-fitting dentures or the edentulous state (Joyston-Bechal, 1965; Evans, 1965). Similar dyskinesias are also said to occur with brain damage when phenothiazines have not been given (Rosin and Exton-Smith, 1965).
SUMMARY Infant mortality rates vary from area to area. Part of this variation is due to the socioeconomic characteristics of the area and part to other factors including the obstetric, paediatric, and community health services. Four social indicators associated with infant deaths are used to control for some of the variations in socioeconomic characteristics and residual variation is then examined. The four social indicators are the level of unemployment, the proportion of large families, the proportion of lone-parent families, and the level of overcrowding.
Diagnostic methodology and treatment modalities for the 2-year periods before and after (2010-11) the specialist MDT formation are given in the table (Table 1). There was no difference in histological rates (100% and 92% respectively) or cell types between the two periods. Conclusions In the second time period, our use of radical oncological treatment increased and at the same time extensive surgical treatment decreased, in keeping with current considered best practice. These changes in clinical practice coincided with discussion of these cases at the newly formed MCCN specialist mesothelioma MDT. This study emphasises the value of an expert multidisciplinary approach to the management of this unfortunate group of patients.
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