To provide new insights into the neural mechanisms of physiological and behavioral responses to stressors in sheep, acute changes in endocrine, autonomic and behavioral functions following 30 min infusions of ovine-corticotropin-releasing hormone (oCRH; 0, 0.5, 5 or 50 m g/0.5 mL of artificial cerebrospinal fluid/30 min) into the third ventricle of sheep ( n = 7-8) were examined. Serial blood samples were collected through indwelling jugular catheters to determine plasma cortisol concentrations (CORT). Heart rate (HR) and rectal temperature (RT) were obtained via telemetry systems. The behaviors of the animal were monitored simultaneously. Intracerebroventricular infusions of CRH dose-dependently induced an increase in CORT; there was a time-treatment interaction in CORT ( P < 0.001). There was not a time-treatment interaction either in HR ( P = 0.29) or in RT ( P = 0.28). That RT showed a tendency to decrease with higher doses of CRH in sheep was in contradiction to previous reports in rats and pigs. As to changes in behavioral function, only the induction of bleating was marked. These results suggest that in physiological and behavioral responses of sheep to stressors, CRH regulates the increase in CORT and the induction of bleating. However, CRH might have little function in sympathetic nervous activation during physiological responses to stressors in sheep.
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