No abstract

No abstract

No abstract

Whole-organ/body three-dimensional (3D) staining and imaging have been enduring challenges in histology. By dissecting the complex physicochemical environment of the staining system, we developed a highly optimized 3D staining imaging pipeline based on CUBIC. Based on our precise characterization of biological tissues as an electrolyte gel, we experimentally evaluated broad 3D staining conditions by using an artificial tissue-mimicking material. The combination of optimized conditions allows a bottom-up design of a superior 3D staining protocol that can uniformly label whole adult mouse brains, an adult marmoset brain hemisphere, an ~1 cm3 tissue block of a postmortem adult human cerebellum, and an entire infant marmoset body with dozens of antibodies and cell-impermeant nuclear stains. The whole-organ 3D images collected by light-sheet microscopy are used for computational analyses and whole-organ comparison analysis between species. This pipeline, named CUBIC-HistoVIsion, thus offers advanced opportunities for organ- and organism-scale histological analysis of multicellular systems.

We present a measurement of angular observables and a test of lepton flavor universality in the B → K * + − decay, where is either e or µ. The analysis is performed on a data sample corresponding to an integrated luminosity of 711 fb −1 containing 772 × 10 6 B B pairs, collected at the Υ(4S) resonance with the Belle detector at the asymmetric-energy e + e − collider KEKB. The result is consistent with Standard Model (SM) expectations, where the largest discrepancy from a SM prediction is observed in the muon modes with a local significance of 2.6σ.

No abstract

We report a measurement of the ratios of branching fractions R(D, where denotes an electron or a muon. The results are based on a data sample containing 772 × 10 6 B B events recorded at the Υ(4S) resonance with the Belle detector at the KEKB e + e − collider. The tag-side B meson is reconstructed in a semileptonic decay mode, and the signal-side τ is reconstructed in a purely leptonic decay. The results are R(D) = 0.307 ± 0.037 ± 0.016 and R(D * ) = 0.283 ± 0.018 ± 0.014, where the first uncertainties are statistical and the second are systematic. These results are in agreement with the Standard Model predictions within 0.2 and 1.1 standard deviations, respectively.

No abstract