Key Points Question Were the Liaison Committee on Medical Education 2009 diversity accreditation guidelines associated with decreased underrepresentation of minorities in medicine? Findings In this cross-sectional study of self-reported race/ethnicity of US medical school matriculants from 2002 to 2017, numbers and proportions of black, Hispanic, and American Indian or Alaska Native medical school matriculants increased, but at a rate slower than their age-matched counterparts in the US population, resulting in increased underrepresentation. Meaning This study suggests that while absolute numbers of physicians from minority racial/ethnic groups have increased over time, the physician workforce still does not represent the demographic characteristics of the US population.

Human MDA5 deficiency features recurrent severe human rhinovirus (HRV) infections. MDA5 serves a protective and nonredundant role in protecting against HRV in the respiratory tract, through its effects on virus sensing and triggering of antiviral IFN signaling.

Zhang et al. show that DOCK8-deficient T and NK cells develop cell and nuclear shape abnormalities that do not impair chemotaxis but contribute to a form of cell death they term cytothripsis. Cytothripsis of DOCK8-deficient cells prevents the generation of long-lived skin-resident memory CD8 T cells resulting in impaired immune response to skin infection.